Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation
ObjectivePre-eclampsia (PE) is one of the malignant metabolic diseases that complicate pregnancy. Gut dysbiosis has been identified for causing metabolic diseases, but the role of gut microbiome in the pathogenesis of PE remains unknown.DesignWe performed a case–control study to compare the faecal m...
Saved in:
| Published in | Gut Vol. 69; no. 3; pp. 513 - 522 |
|---|---|
| Main Authors | , , , , , , , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
BMJ Publishing Group Ltd and British Society of Gastroenterology
01.03.2020
BMJ Publishing Group LTD |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | ObjectivePre-eclampsia (PE) is one of the malignant metabolic diseases that complicate pregnancy. Gut dysbiosis has been identified for causing metabolic diseases, but the role of gut microbiome in the pathogenesis of PE remains unknown.DesignWe performed a case–control study to compare the faecal microbiome of PE and normotensive pregnant women by 16S ribosomal RNA (rRNA) sequencing. To address the causative relationship between gut dysbiosis and PE, we used faecal microbiota transplantation (FMT) in an antibiotic-treated mouse model. Finally, we determined the microbiome translocation and immune responses in human and mouse placental samples by 16S rRNA sequencing, quantitative PCR and in situ hybridisation.ResultsPatients with PE showed reduced bacterial diversity with obvious dysbiosis. Opportunistic pathogens, particularly Fusobacterium and Veillonella, were enriched, whereas beneficial bacteria, including Faecalibacterium and Akkermansia, were markedly depleted in the PE group. The abundances of these discriminative bacteria were correlated with blood pressure (BP), proteinuria, aminotransferase and creatinine levels. On successful colonisation, the gut microbiome from patients with PE triggered a dramatic, increased pregestational BP of recipient mice, which further increased after gestation. In addition, the PE-transplanted group showed increased proteinuria, embryonic resorption and lower fetal and placental weights. Their T regulatory/helper-17 balance in the small intestine and spleen was disturbed with more severe intestinal leakage. In the placenta of both patients with PE and PE-FMT mice, the total bacteria, Fusobacterium, and inflammatory cytokine levels were significantly increased.ConclusionsThis study suggests that the gut microbiome of patients with PE is dysbiotic and contributes to disease pathogenesis. |
|---|---|
| AbstractList | ObjectivePre-eclampsia (PE) is one of the malignant metabolic diseases that complicate pregnancy. Gut dysbiosis has been identified for causing metabolic diseases, but the role of gut microbiome in the pathogenesis of PE remains unknown.DesignWe performed a case–control study to compare the faecal microbiome of PE and normotensive pregnant women by 16S ribosomal RNA (rRNA) sequencing. To address the causative relationship between gut dysbiosis and PE, we used faecal microbiota transplantation (FMT) in an antibiotic-treated mouse model. Finally, we determined the microbiome translocation and immune responses in human and mouse placental samples by 16S rRNA sequencing, quantitative PCR and in situ hybridisation.ResultsPatients with PE showed reduced bacterial diversity with obvious dysbiosis. Opportunistic pathogens, particularly Fusobacterium and Veillonella, were enriched, whereas beneficial bacteria, including Faecalibacterium and Akkermansia, were markedly depleted in the PE group. The abundances of these discriminative bacteria were correlated with blood pressure (BP), proteinuria, aminotransferase and creatinine levels. On successful colonisation, the gut microbiome from patients with PE triggered a dramatic, increased pregestational BP of recipient mice, which further increased after gestation. In addition, the PE-transplanted group showed increased proteinuria, embryonic resorption and lower fetal and placental weights. Their T regulatory/helper-17 balance in the small intestine and spleen was disturbed with more severe intestinal leakage. In the placenta of both patients with PE and PE-FMT mice, the total bacteria, Fusobacterium, and inflammatory cytokine levels were significantly increased.ConclusionsThis study suggests that the gut microbiome of patients with PE is dysbiotic and contributes to disease pathogenesis. Pre-eclampsia (PE) is one of the malignant metabolic diseases that complicate pregnancy. Gut dysbiosis has been identified for causing metabolic diseases, but the role of gut microbiome in the pathogenesis of PE remains unknown. We performed a case-control study to compare the faecal microbiome of PE and normotensive pregnant women by 16S ribosomal RNA (rRNA) sequencing. To address the causative relationship between gut dysbiosis and PE, we used faecal microbiota transplantation (FMT) in an antibiotic-treated mouse model. Finally, we determined the microbiome translocation and immune responses in human and mouse placental samples by 16S rRNA sequencing, quantitative PCR and in situ hybridisation. Patients with PE showed reduced bacterial diversity with obvious dysbiosis. Opportunistic pathogens, particularly and , were enriched, whereas beneficial bacteria, including and , were markedly depleted in the PE group. The abundances of these discriminative bacteria were correlated with blood pressure (BP), proteinuria, aminotransferase and creatinine levels. On successful colonisation, the gut microbiome from patients with PE triggered a dramatic, increased pregestational BP of recipient mice, which further increased after gestation. In addition, the PE-transplanted group showed increased proteinuria, embryonic resorption and lower fetal and placental weights. Their T regulatory/helper-17 balance in the small intestine and spleen was disturbed with more severe intestinal leakage. In the placenta of both patients with PE and PE-FMT mice, the total bacteria, , and inflammatory cytokine levels were significantly increased. This study suggests that the gut microbiome of patients with PE is dysbiotic and contributes to disease pathogenesis. Pre-eclampsia (PE) is one of the malignant metabolic diseases that complicate pregnancy. Gut dysbiosis has been identified for causing metabolic diseases, but the role of gut microbiome in the pathogenesis of PE remains unknown.OBJECTIVEPre-eclampsia (PE) is one of the malignant metabolic diseases that complicate pregnancy. Gut dysbiosis has been identified for causing metabolic diseases, but the role of gut microbiome in the pathogenesis of PE remains unknown.We performed a case-control study to compare the faecal microbiome of PE and normotensive pregnant women by 16S ribosomal RNA (rRNA) sequencing. To address the causative relationship between gut dysbiosis and PE, we used faecal microbiota transplantation (FMT) in an antibiotic-treated mouse model. Finally, we determined the microbiome translocation and immune responses in human and mouse placental samples by 16S rRNA sequencing, quantitative PCR and in situ hybridisation.DESIGNWe performed a case-control study to compare the faecal microbiome of PE and normotensive pregnant women by 16S ribosomal RNA (rRNA) sequencing. To address the causative relationship between gut dysbiosis and PE, we used faecal microbiota transplantation (FMT) in an antibiotic-treated mouse model. Finally, we determined the microbiome translocation and immune responses in human and mouse placental samples by 16S rRNA sequencing, quantitative PCR and in situ hybridisation.Patients with PE showed reduced bacterial diversity with obvious dysbiosis. Opportunistic pathogens, particularly Fusobacterium and Veillonella, were enriched, whereas beneficial bacteria, including Faecalibacterium and Akkermansia, were markedly depleted in the PE group. The abundances of these discriminative bacteria were correlated with blood pressure (BP), proteinuria, aminotransferase and creatinine levels. On successful colonisation, the gut microbiome from patients with PE triggered a dramatic, increased pregestational BP of recipient mice, which further increased after gestation. In addition, the PE-transplanted group showed increased proteinuria, embryonic resorption and lower fetal and placental weights. Their T regulatory/helper-17 balance in the small intestine and spleen was disturbed with more severe intestinal leakage. In the placenta of both patients with PE and PE-FMT mice, the total bacteria, Fusobacterium, and inflammatory cytokine levels were significantly increased.RESULTSPatients with PE showed reduced bacterial diversity with obvious dysbiosis. Opportunistic pathogens, particularly Fusobacterium and Veillonella, were enriched, whereas beneficial bacteria, including Faecalibacterium and Akkermansia, were markedly depleted in the PE group. The abundances of these discriminative bacteria were correlated with blood pressure (BP), proteinuria, aminotransferase and creatinine levels. On successful colonisation, the gut microbiome from patients with PE triggered a dramatic, increased pregestational BP of recipient mice, which further increased after gestation. In addition, the PE-transplanted group showed increased proteinuria, embryonic resorption and lower fetal and placental weights. Their T regulatory/helper-17 balance in the small intestine and spleen was disturbed with more severe intestinal leakage. In the placenta of both patients with PE and PE-FMT mice, the total bacteria, Fusobacterium, and inflammatory cytokine levels were significantly increased.This study suggests that the gut microbiome of patients with PE is dysbiotic and contributes to disease pathogenesis.CONCLUSIONSThis study suggests that the gut microbiome of patients with PE is dysbiotic and contributes to disease pathogenesis. |
| Author | Huang, Liping He, Yan Wang, Zhijian Tang, Wenli Hu, Haoyue Feng, Yinglin Chen, Xia Ke, Guibao Li, Pan Zhong, Mei Huang, Yongxin Zhou, Hongwei Liu, Mian Chen, Yun Yue, Xiaojing Zheng, Huimin Zhuang, Lingling Yu, Yanhong Chen, Mu-Xuan |
| Author_xml | – sequence: 1 givenname: Xia orcidid: 0000-0002-7915-4568 surname: Chen fullname: Chen, Xia organization: Department of Obstetrics and Gynecology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China – sequence: 2 givenname: Pan surname: Li fullname: Li, Pan organization: Microbiome Medicine Center, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China – sequence: 3 givenname: Mian surname: Liu fullname: Liu, Mian organization: Department of Obstetrics and Gynecology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China – sequence: 4 givenname: Huimin surname: Zheng fullname: Zheng, Huimin organization: Microbiome Research Centre, St George and Sutherland Clinical School, University of New South Wales, Sydney, New South Wales, Australia – sequence: 5 givenname: Yan surname: He fullname: He, Yan organization: Microbiome Medicine Center, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China – sequence: 6 givenname: Mu-Xuan surname: Chen fullname: Chen, Mu-Xuan organization: Microbiome Medicine Center, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China – sequence: 7 givenname: Wenli surname: Tang fullname: Tang, Wenli organization: Microbiome Medicine Center, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China – sequence: 8 givenname: Xiaojing surname: Yue fullname: Yue, Xiaojing organization: Department of Obstetrics and Gynecology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China – sequence: 9 givenname: Yongxin surname: Huang fullname: Huang, Yongxin organization: Department of Obstetrics and Gynecology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China – sequence: 10 givenname: Lingling surname: Zhuang fullname: Zhuang, Lingling organization: Department of Obstetrics and Gynecology, First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China – sequence: 11 givenname: Zhijian surname: Wang fullname: Wang, Zhijian organization: Department of Obstetrics and Gynecology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China – sequence: 12 givenname: Mei surname: Zhong fullname: Zhong, Mei organization: Department of Obstetrics and Gynecology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China – sequence: 13 givenname: Guibao surname: Ke fullname: Ke, Guibao organization: Department of Internal Medicine, Affiliated Hospital, Chengdu University, Chengdu, Sichuan, China – sequence: 14 givenname: Haoyue surname: Hu fullname: Hu, Haoyue organization: Department of Obstetrics and Gynecology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China – sequence: 15 givenname: Yinglin surname: Feng fullname: Feng, Yinglin organization: Department of Obstetrics and Gynecology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China – sequence: 16 givenname: Yun surname: Chen fullname: Chen, Yun organization: Department of Obstetrics and Gynecology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China – sequence: 17 givenname: Yanhong surname: Yu fullname: Yu, Yanhong email: yuyh1010@hotmail.com organization: Department of Obstetrics and Gynecology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China – sequence: 18 givenname: Hongwei surname: Zhou fullname: Zhou, Hongwei email: hzhou@smu.edu.cn organization: Microbiome Medicine Center, Division of Laboratory Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China – sequence: 19 givenname: Liping surname: Huang fullname: Huang, Liping email: lphuang2006@126.com organization: Department of Obstetrics and Gynecology, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31900289$$D View this record in MEDLINE/PubMed |
| BookMark | eNqN0U1rFTEUBuAgFXtb_QMuZMCNm9R83MkkSylahYIbdTvk40ybSyYZk4zQf2_aaSt0UVxl87wnyXlP0FFMERB6S8kZpVx8vFrrIQbMCFWYU0UJfYF2dC8k5kzKI7QjhA64H_bqGJ2UciCESKnoK3TcNCFMqh36dbHWzt0U41PxpfPRrRZKV6-hc_AHQlpmiLVLU7dkwGCDnpfidQM5rVfXndG2QvY6dDXrWEKyuvoUX6OXkw4F3tyfp-jnl88_zr_iy-8X384_XWLTU1mxGwCMGdQk1GAduL01pB-kU8RaLSYpmFZSSKWscXKv-OSYGSwMUlrGRK_4KfqwzV1y-r1CqePsi4UQdIS0lpFxzgXpmaCNvn9CD2nNsb2uqb6NE4yLpt7dq9XM4MYl-1nnm_FhYw2wDdicSskwPRJKxttaxq2W8baWcaulheSTkPX1blFtaz48H8Vb1MyH_7vq7J9__OEzgb_xU7HC |
| CitedBy_id | crossref_primary_10_3389_fmicb_2023_1123444 crossref_primary_10_3390_microorganisms9081686 crossref_primary_10_1186_s13046_021_01845_6 crossref_primary_10_3389_fphar_2021_726707 crossref_primary_10_1152_physiolgenomics_00004_2023 crossref_primary_10_1038_s41522_024_00630_5 crossref_primary_10_1080_01443615_2022_2114822 crossref_primary_10_12677_ACM_2022_12111490 crossref_primary_10_1039_D1FO03145G crossref_primary_10_1016_j_preghy_2021_04_002 crossref_primary_10_1007_s00737_023_01300_9 crossref_primary_10_1016_j_aninu_2022_11_002 crossref_primary_10_1186_s40168_025_02032_x crossref_primary_10_1007_s11427_022_2320_y crossref_primary_10_1186_s13073_021_01005_7 crossref_primary_10_1371_journal_pone_0253453 crossref_primary_10_1186_s13020_024_01016_7 crossref_primary_10_1097_HC9_0000000000000221 crossref_primary_10_1158_1078_0432_CCR_20_3445 crossref_primary_10_1080_14767058_2023_2228964 crossref_primary_10_1136_gutjnl_2020_322090 crossref_primary_10_1016_j_jep_2024_119217 crossref_primary_10_1186_s12967_022_03296_9 crossref_primary_10_1128_msphere_00676_23 crossref_primary_10_1016_j_retram_2022_103354 crossref_primary_10_1186_s13568_023_01646_4 crossref_primary_10_3390_nu14214582 crossref_primary_10_1007_s00424_023_02810_2 crossref_primary_10_1038_s41421_025_00789_x crossref_primary_10_3389_fcimb_2022_1071029 crossref_primary_10_1016_j_xcrm_2024_101678 crossref_primary_10_3389_fcimb_2025_1521754 crossref_primary_10_1093_jas_skad021 crossref_primary_10_1080_10641963_2023_2195135 crossref_primary_10_1111_jcpe_13833 crossref_primary_10_3389_fmed_2020_620102 crossref_primary_10_1155_2022_6367264 crossref_primary_10_1371_journal_ppat_1011764 crossref_primary_10_2147_DDDT_S443462 crossref_primary_10_1038_s41467_023_36981_4 crossref_primary_10_2147_JIR_S337031 crossref_primary_10_1186_s12916_024_03797_y crossref_primary_10_14390_jsshp_HRP2021_013 crossref_primary_10_3389_fendo_2024_1423464 crossref_primary_10_18632_aging_205019 crossref_primary_10_2139_ssrn_4191821 crossref_primary_10_1080_20002297_2021_1883382 crossref_primary_10_15252_embr_202255664 crossref_primary_10_1111_jam_15620 crossref_primary_10_1016_j_ecoenv_2023_114890 crossref_primary_10_3389_fcell_2024_1384233 crossref_primary_10_1016_j_envint_2023_107802 crossref_primary_10_1186_s40168_022_01402_z crossref_primary_10_1021_acs_jafc_3c06647 crossref_primary_10_3390_ijms24032471 crossref_primary_10_1016_j_ecoenv_2020_111143 crossref_primary_10_1089_vim_2023_0096 crossref_primary_10_3390_biom13020346 crossref_primary_10_1016_j_phrs_2020_104692 crossref_primary_10_3389_fbrio_2023_1322165 crossref_primary_10_1016_j_cca_2024_119922 crossref_primary_10_1016_j_jri_2025_104423 crossref_primary_10_3389_fcimb_2022_933523 crossref_primary_10_1038_s41522_023_00374_8 crossref_primary_10_1128_msphere_00096_23 crossref_primary_10_3390_ijms23031831 crossref_primary_10_3390_ijerph20186736 crossref_primary_10_1016_j_jhazmat_2021_126707 crossref_primary_10_3390_life14070902 crossref_primary_10_3389_fcimb_2022_1022857 crossref_primary_10_1080_10408398_2022_2117784 crossref_primary_10_7189_jogh_14_04177 crossref_primary_10_3389_fmicb_2024_1456087 crossref_primary_10_1111_aji_13802 crossref_primary_10_3390_antiox13020141 crossref_primary_10_1093_nar_gkad813 crossref_primary_10_3389_fcimb_2024_1446580 crossref_primary_10_1360_SSV_2021_0060 crossref_primary_10_3389_fgwh_2022_810673 crossref_primary_10_1016_j_fbio_2023_103397 crossref_primary_10_1055_a_2273_6318 crossref_primary_10_1097_AOG_0000000000005345 crossref_primary_10_3389_fcimb_2023_1177768 crossref_primary_10_1038_s41598_024_83981_5 crossref_primary_10_1016_j_heliyon_2024_e24698 crossref_primary_10_1016_j_medmic_2021_100047 crossref_primary_10_1016_j_medmic_2021_100046 crossref_primary_10_1016_j_clp_2024_02_009 crossref_primary_10_1038_s41581_022_00654_0 crossref_primary_10_1186_s12967_021_02814_5 crossref_primary_10_1111_jam_15279 crossref_primary_10_1007_s10735_024_10243_z crossref_primary_10_1016_j_medmic_2021_100045 crossref_primary_10_3389_fcimb_2021_671347 crossref_primary_10_3389_fcimb_2024_1352267 crossref_primary_10_1016_j_hazadv_2022_100222 crossref_primary_10_1016_j_celrep_2022_111681 crossref_primary_10_1136_gutjnl_2022_329312 crossref_primary_10_1016_j_envint_2020_106164 crossref_primary_10_1186_s40168_023_01528_8 crossref_primary_10_3389_fphar_2021_643283 crossref_primary_10_1016_j_cnd_2024_04_006 crossref_primary_10_1016_j_jare_2023_02_009 crossref_primary_10_1152_physiolgenomics_00121_2020 crossref_primary_10_3389_fcimb_2021_579766 crossref_primary_10_1186_s12884_024_06930_0 crossref_primary_10_1111_aji_70003 crossref_primary_10_3389_fcimb_2023_1256940 crossref_primary_10_3389_fmicb_2024_1451170 crossref_primary_10_1016_j_chom_2023_03_018 crossref_primary_10_1038_s41467_021_24516_8 crossref_primary_10_1177_09287329251316227 crossref_primary_10_1007_s43032_023_01206_y crossref_primary_10_1016_j_bpobgyn_2023_102427 crossref_primary_10_3389_fcimb_2022_859708 crossref_primary_10_1016_j_jnutbio_2022_109172 crossref_primary_10_1186_s12951_024_02997_1 crossref_primary_10_3390_microorganisms13020245 crossref_primary_10_1080_19490976_2021_1894070 crossref_primary_10_5534_wjmh_230337 crossref_primary_10_12677_acm_2024_1461820 crossref_primary_10_1038_s41598_024_57481_5 crossref_primary_10_17816_JOWD69441_50 crossref_primary_10_3390_microorganisms11092217 crossref_primary_10_3389_fimmu_2024_1362784 crossref_primary_10_3389_fcimb_2022_646165 crossref_primary_10_3390_biomedicines13010121 crossref_primary_10_1152_physrev_00050_2021 crossref_primary_10_3389_fcimb_2023_1105126 crossref_primary_10_5812_jjm_136914 crossref_primary_10_14814_phy2_15982 crossref_primary_10_1002_imt2_167 crossref_primary_10_1016_j_coemr_2021_03_004 crossref_primary_10_3389_fmicb_2023_1114228 crossref_primary_10_1007_s00284_023_03252_w crossref_primary_10_1155_2022_5075569 crossref_primary_10_1016_j_lfs_2024_122744 crossref_primary_10_3390_microorganisms9030473 crossref_primary_10_1002_imt2_270 crossref_primary_10_1016_j_isci_2024_111484 crossref_primary_10_1186_s12884_024_06604_x crossref_primary_10_12677_ACM_2023_13112430 crossref_primary_10_1038_s41598_023_43780_w crossref_primary_10_1186_s12866_021_02327_7 crossref_primary_10_1038_s41572_023_00417_6 crossref_primary_10_3390_healthcare10081503 crossref_primary_10_1016_j_ecoenv_2022_113467 crossref_primary_10_1039_D3NA00696D crossref_primary_10_3389_fped_2022_935458 crossref_primary_10_3390_microorganisms8121996 crossref_primary_10_1186_s40795_024_00972_5 crossref_primary_10_3390_ani13121999 crossref_primary_10_1016_j_eclinm_2023_101963 crossref_primary_10_7717_peerj_15605 crossref_primary_10_1186_s13098_022_00954_2 crossref_primary_10_3389_fmed_2023_1168625 crossref_primary_10_1186_s12916_022_02657_x crossref_primary_10_12998_wjcc_v10_i10_2976 crossref_primary_10_1186_s12916_023_02975_8 crossref_primary_10_1016_j_ajog_2021_11_1356 crossref_primary_10_1016_j_mib_2023_102309 crossref_primary_10_1515_mr_2021_0002 crossref_primary_10_3389_fendo_2023_1267195 crossref_primary_10_3390_biom13060911 crossref_primary_10_1016_j_jhazmat_2025_137573 crossref_primary_10_3390_cimb45080391 crossref_primary_10_1126_sciadv_adi7337 crossref_primary_10_3389_fcimb_2022_1025714 crossref_primary_10_3390_nu14235025 crossref_primary_10_1080_19490976_2024_2311888 crossref_primary_10_1093_gpbjnl_qzad005 crossref_primary_10_1093_lifemeta_load052 crossref_primary_10_1002_ptr_7813 crossref_primary_10_1371_journal_ppat_1011108 crossref_primary_10_1016_j_scitotenv_2020_141030 crossref_primary_10_17816_JOWD625424 crossref_primary_10_3389_abp_2024_12020 crossref_primary_10_1016_j_jare_2024_02_014 crossref_primary_10_1016_j_phymed_2024_156254 crossref_primary_10_1097_HJH_0000000000002908 crossref_primary_10_1016_j_micres_2024_127788 crossref_primary_10_1016_j_intimp_2024_113919 crossref_primary_10_1152_ajpregu_00020_2020 crossref_primary_10_3390_microorganisms12122483 crossref_primary_10_1016_j_bbi_2022_06_006 crossref_primary_10_3389_fmolb_2024_1420664 crossref_primary_10_1128_msystems_01301_23 crossref_primary_10_1186_s10020_023_00689_4 crossref_primary_10_1016_j_chom_2024_02_012 crossref_primary_10_1186_s40168_024_01749_5 crossref_primary_10_7759_cureus_62995 crossref_primary_10_1016_j_ebiom_2023_104959 crossref_primary_10_1038_s41380_024_02794_0 crossref_primary_10_1016_j_phymed_2024_156000 crossref_primary_10_1021_acs_jafc_3c00399 crossref_primary_10_1016_j_cmet_2024_08_007 crossref_primary_10_62347_CSJL6508 crossref_primary_10_3390_nu15122723 crossref_primary_10_1016_j_celrep_2024_114585 crossref_primary_10_1016_j_placenta_2024_10_013 crossref_primary_10_1186_s40168_021_01178_8 crossref_primary_10_5385_nm_2023_30_4_89 crossref_primary_10_1128_spectrum_00076_23 crossref_primary_10_1016_j_jnutbio_2024_109708 crossref_primary_10_1002_jev2_12328 crossref_primary_10_3389_fcimb_2024_1469054 crossref_primary_10_3390_ijms251810099 crossref_primary_10_1016_j_placenta_2020_02_011 crossref_primary_10_3389_fendo_2023_1304727 crossref_primary_10_1016_j_biopha_2023_114429 crossref_primary_10_1556_650_2021_32082 crossref_primary_10_1161_CIRCRESAHA_122_320771 crossref_primary_10_1016_j_ecoenv_2022_113550 crossref_primary_10_1186_s12866_024_03255_y crossref_primary_10_3389_fmicb_2022_1059281 crossref_primary_10_1016_j_crmicr_2025_100366 |
| Cites_doi | 10.1016/S0723-2020(99)80053-8 10.1016/j.chom.2013.07.012 10.1016/j.atherosclerosis.2004.01.038 10.1186/s40168-016-0222-x 10.1902/jop.2007.060362 10.1038/s41586-019-1451-5 10.1093/bioinformatics/btq461 10.1002/jcp.27315 10.1126/science.aar7201 10.1042/CS20180087 10.1038/s41571-018-0006-2 10.1111/jog.12619 10.1038/s41564-018-0202-y 10.1111/aji.13086 10.1002/uog.20126 10.1038/ismej.2011.139 10.1111/jgh.12694 10.1007/s11255-018-1873-2 10.1038/nmeth.1650 10.1038/nmeth.1650 10.1136/gutjnl-2015-310500 10.1007/s10995-007-0224-1 10.3390/nu10080988 10.3791/52836 10.1073/pnas.1502875112 10.1159/000479439 10.1016/S0140-6736(15)00070-7 10.1016/j.ajpath.2014.05.003 10.1016/j.ajog.2019.04.036 10.3389/fcimb.2019.00224 10.1097/AOG.0000000000003018 10.1038/s41591-018-0164-x 10.4103/1119-3077.180055 10.1007/s10096-016-2853-z 10.1016/j.cell.2017.07.008 10.1016/j.cell.2012.07.008 10.1002/hep.30361 10.1186/gb-2011-12-6-r60 10.1186/s40168-018-0605-2 10.1053/j.gastro.2013.04.011 10.1161/HYPERTENSIONAHA.117.10803 10.1159/000354200 10.1038/nrmicro3089 10.1136/gutjnl-2018-315988 10.1016/j.mib.2014.11.013 10.1016/j.immuni.2018.12.015 10.1095/biolreprod.111.097014 10.1038/cmi.2017.70 10.1038/s41586-019-1628-y 10.1038/nmeth.1650 10.1214/aos/1013699998 |
| ContentType | Journal Article |
| Copyright | Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. 2020 Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| Copyright_xml | – notice: Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. – notice: Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. – notice: 2020 Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. |
| DBID | 9YT ACMMV AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 88I 8AF 8FE 8FH 8FI 8FJ 8FK ABUWG AFKRA AZQEC BBNVY BENPR BHPHI BTHHO CCPQU DWQXO FYUFA GHDGH GNUQQ HCIFZ K9. LK8 M0S M1P M2P M7P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PRINS Q9U 7X8 |
| DOI | 10.1136/gutjnl-2019-319101 |
| DatabaseName | BMJ Open Access Journals (Free internet resource, activated by CARLI) BMJ Journals:Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) Science Database (Alumni Edition) STEM Database ProQuest SciTech Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials Biological Science Collection ProQuest Central Natural Science Collection BMJ Journals ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student SciTech Premium Collection ProQuest Health & Medical Complete (Alumni) Biological Sciences Health & Medical Collection (Alumni) Medical Database Science Database Biological Science Database ProQuest Central Premium ProQuest One Academic ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest AP Science ProQuest Central (Alumni Edition) SciTech Premium Collection ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Central China ProQuest Central ProQuest One Applied & Life Sciences ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Natural Science Collection ProQuest Central Korea Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Science Journals (Alumni Edition) ProQuest Biological Science Collection ProQuest Central Basic ProQuest Science Journals ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) Biological Science Database ProQuest SciTech Collection ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition BMJ Journals ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE ProQuest Central Student MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: ACMMV name: BMJ Journals:Open Access url: https://journals.bmj.com/ sourceTypes: Publisher – sequence: 4 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1468-3288 |
| EndPage | 522 |
| ExternalDocumentID | 31900289 10_1136_gutjnl_2019_319101 gutjnl |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GeographicLocations | United States--US China California |
| GeographicLocations_xml | – name: China – name: United States--US – name: California |
| GrantInformation_xml | – fundername: National Key Research and Development Program of China grantid: 2019YFA0802300 – fundername: Natural Science Foundation of Guangdong Province grantid: 2017A010105025 funderid: http://dx.doi.org/10.13039/501100003453 – fundername: China Postdoctoral Science Foundation grantid: 2018M633077 funderid: http://dx.doi.org/10.13039/501100002858 – fundername: National Natural Science Foundation of China grantid: 81925026, 81703078, 81771609, 81800746 and 3157049 funderid: http://dx.doi.org/10.13039/501100001809 |
| GroupedDBID | --- .55 .GJ .VT 08G 0R~ 18M 29I 2WC 354 39C 3O- 4.4 40O 53G 5GY 5VS 7X7 7~S 88E 88I 8AF 8F7 8FE 8FH 8FI 8FJ 8R4 8R5 9YT AAHLL AAKAS AAOJX AAUVZ AAWJN AAYEP ABAAH ABKDF ABMQD ABOCM ABTFR ABUWG ABVAJ ACGFO ACGFS ACGOD ACGTL ACHTP ACMFJ ACMMV ACOAB ACOFX ACQSR ACTZY ADBBV ADCEG ADFRT ADUGQ ADZCM AENEX AFKRA AFWFF AGQPQ AHMBA AHNKE AHQMW AI. AJYBZ ALIPV ALMA_UNASSIGNED_HOLDINGS ASPBG AVWKF AZFZN AZQEC BAWUL BBNVY BENPR BHPHI BLJBA BOMFT BPHCQ BTFSW BTHHO BVXVI C1A C45 CAG CCPQU COF CS3 CXRWF DIK DU5 DWQXO E3Z EBS EJD F5P FD8 FEDTE FYUFA GNUQQ GX1 H13 HAJ HCIFZ HMCUK HVGLF HYE HZ~ IAO IEA IH2 IHR INH INR IOF ITC J5H KQ8 L7B LK8 M1P M2P M7P N9A NTWIH NXWIF O9- OK1 OVD P2P PHGZT PQQKQ PROAC PSQYO Q2X R53 RHI RMJ RPM RV8 TEORI TR2 UKHRP UYXKK V24 VH1 VM9 VVN W8F WH7 WOQ X7M YFH YOC YQY ZGI ZXP ZY1 AAYXX ACQHZ ADGHP AERUA CITATION PHGZM 3V. CGR CUY CVF ECM EIF NPM PKN RHF 7XB 8FK K9. PJZUB PKEHL PPXIY PQEST PQGLB PQUKI PRINS Q9U 7X8 |
| ID | FETCH-LOGICAL-b518t-d7eebb79f697cded4cb0578d90cca6f862a986899cbd8493fd2b7ce788c226593 |
| IEDL.DBID | 9YT |
| ISSN | 0017-5749 1468-3288 |
| IngestDate | Fri Jul 11 02:02:11 EDT 2025 Fri Jul 25 11:41:11 EDT 2025 Wed Feb 19 02:31:19 EST 2025 Tue Jul 01 02:49:09 EDT 2025 Thu Apr 24 22:55:07 EDT 2025 Thu Apr 24 22:53:42 EDT 2025 Thu Apr 24 22:50:14 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 3 |
| Keywords | bacterial translocation intestinal bacteria intestinal barrier function immunology |
| Language | English |
| License | This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/. Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-b518t-d7eebb79f697cded4cb0578d90cca6f862a986899cbd8493fd2b7ce788c226593 |
| Notes | Original research ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| ORCID | 0000-0002-7915-4568 |
| OpenAccessLink | https://gut.bmj.com/content/69/3/513.full |
| PMID | 31900289 |
| PQID | 2352266236 |
| PQPubID | 2041069 |
| PageCount | 10 |
| ParticipantIDs | proquest_miscellaneous_2333605261 proquest_journals_2352266236 pubmed_primary_31900289 crossref_primary_10_1136_gutjnl_2019_319101 crossref_citationtrail_10_1136_gutjnl_2019_319101 bmj_primary_10_1136_gutjnl_2019_319101 bmj_journals_10_1136_gutjnl_2019_319101 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-03-01 |
| PublicationDateYYYYMMDD | 2020-03-01 |
| PublicationDate_xml | – month: 03 year: 2020 text: 2020-03-01 day: 01 |
| PublicationDecade | 2020 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England – name: London |
| PublicationTitle | Gut |
| PublicationTitleAbbrev | Gut |
| PublicationTitleAlternate | Gut |
| PublicationYear | 2020 |
| Publisher | BMJ Publishing Group Ltd and British Society of Gastroenterology BMJ Publishing Group LTD |
| Publisher_xml | – name: BMJ Publishing Group Ltd and British Society of Gastroenterology – name: BMJ Publishing Group LTD |
| References | Davis, Proctor, Holmes (R23) 2018; 6 Wu, Peng, Kuo (R29) 2014; 184 Jabalie, Ahmadi, Koushaeian (R5) 2019; 81 Lv, Li, Li (R15) 2019; 9 Britton, Contijoch, Mogno (R47) 2019; 50 Edgar (R20) 2010; 26 Manfredo Vieira, Hiltensperger, Kumar (R30) 2018; 359 Seferovic, Pace, Carroll (R44) 2019; 221 de Goffau, Lager, Sovio (R46) 2019; 572 Hooijschuur, Ghossein-Doha, Kroon (R7) 2019; 54 He, Wu, Zheng (R8) 2018; 24 Koren, Goodrich, Cullender (R48) 2012; 150 Eghbal-Fard, Yousefi, Heydarlou (R26) 2019; 234 Choi, Kim, Baek (R18) 2015 Raghupathy (R31) 2013; 22 Knights, Kuczynski, Charlson (R24) 2011; 8 Kanbay, Onal, Afsar (R13) 2018; 50 Routy, Gopalakrishnan, Daillère (R34) 2018; 15 Chen, Xiu, Xing (R17) 2017; 42 Segata, Izard, Waldron (R22) 2011; 12 Barak, Oettinger-Barak, Machtei (R37) 2007; 78 (R2) 2019; 133 Kim, Goel, Kumar (R12) 2018; 132 de Goffau, Lager, Salter (R45) 2018; 3 Han (R41) 2015; 23 Mol, Roberts, Thangaratinam (R1) 2016; 387 De Cruz, Kang, Wagner (R36) 2015; 30 McDonald, Price, Goodrich (R21) 2012; 6 Hiippala, Jouhten, Ronkainen (R33) 2018; 10 DiGiulio, Callahan, McMurdie (R38) 2015; 112 Wang, Zheng, Shi (R9) 2018; 67 Rodie (R6) 2004; 175 Rubinstein, Wang, Liu (R40) 2013; 14 Liu, Yang, Yin (R14) 2017; 36 Gong, Yan, Liu (R16) 2019; 69 Zhang, Liu, Tian (R27) 2018; 15 Udenze (R4) 2016; 19 Li, Zhao, Wang (R11) 2017; 5 Kummen, Holm, Anmarkrud (R35) 2017; 66 Rustveld, Kelsey, Sharma (R43) 2008; 12 Zhao (R10) 2013; 11 Brown, Magee, Kenny (R3) 2018; 72 Daims, Brühl, Amann (R19) 1999; 22 Yu, Guo, Yu (R39) 2017; 170 Amarasekara, Jayasekara, Senanayake (R42) 2015; 41 Holder, Tower, Jones (R32) 2012; 86 Benjamini, Yekutieli (R25) 2001; 29 Su, Nalle, Shen (R28) 2013; 145 Li, Zhao, Wang 2017; 5 Daims, Brühl, Amann 1999; 22 Brown, Magee, Kenny 2018; 72 de Goffau, Lager, Salter 2018; 3 Koren, Goodrich, Cullender 2012; 150 Kanbay, Onal, Afsar 2018; 50 Kummen, Holm, Anmarkrud 2017; 66 De Cruz, Kang, Wagner 2015; 30 Manfredo Vieira, Hiltensperger, Kumar 2018; 359 Udenze 2016; 19 Benjamini, Yekutieli 2001; 29 Raghupathy 2013; 22 Davis, Proctor, Holmes 2018; 6 Barak, Oettinger-Barak, Machtei 2007; 78 Chen, Xiu, Xing 2017; 42 Hiippala, Jouhten, Ronkainen 2018; 10 Routy, Gopalakrishnan, Daillère 2018; 15 Knights, Kuczynski, Charlson 2011; 8 He, Wu, Zheng 2018; 24 Lv, Li, Li 2019; 9 Yu, Guo, Yu 2017; 170 Liu, Yang, Yin 2017; 36 Wu, Peng, Kuo 2014; 184 Rubinstein, Wang, Liu 2013; 14 Zhao 2013; 11 DiGiulio, Callahan, McMurdie 2015; 112 Kim, Goel, Kumar 2018; 132 Jabalie, Ahmadi, Koushaeian 2019; 81 Hooijschuur, Ghossein-Doha, Kroon 2019; 54 Gong, Yan, Liu 2019; 69 Mol, Roberts, Thangaratinam 2016; 387 McDonald, Price, Goodrich 2012; 6 Seferovic, Pace, Carroll 2019; 221 Wang, Zheng, Shi 2018; 67 Amarasekara, Jayasekara, Senanayake 2015; 41 de Goffau, Lager, Sovio 2019; 572 Britton, Contijoch, Mogno 2019; 50 Zhang, Liu, Tian 2018; 15 Holder, Tower, Jones 2012; 86 Edgar 2010; 26 Segata, Izard, Waldron 2011; 12 Eghbal-Fard, Yousefi, Heydarlou 2019; 234 Han 2015; 23 Rodie 2004; 175 Choi, Kim, Baek 2015 2019; 133 Rustveld, Kelsey, Sharma 2008; 12 Su, Nalle, Shen 2013; 145 2024111101551527000_69.3.513.24 2024111101551527000_69.3.513.46 2024111101551527000_69.3.513.25 2024111101551527000_69.3.513.47 Segata (2024111101551527000_69.3.513.22) 2011; 12 2024111101551527000_69.3.513.23 Udenze (2024111101551527000_69.3.513.4) 2016; 19 Chen (2024111101551527000_69.3.513.17) 2017; 42 2024111101551527000_69.3.513.20 Yu (2024111101551527000_69.3.513.39) 2017; 170 2024111101551527000_69.3.513.42 2024111101551527000_69.3.513.21 2024111101551527000_69.3.513.43 Holder (2024111101551527000_69.3.513.32) 2012; 86 2024111101551527000_69.3.513.40 2024111101551527000_69.3.513.41 2024111101551527000_69.3.513.28 2024111101551527000_69.3.513.29 Hooijschuur (2024111101551527000_69.3.513.7) 2019; 54 Kim (2024111101551527000_69.3.513.12) 2018; 132 Gong (2024111101551527000_69.3.513.16) 2019; 69 2024111101551527000_69.3.513.48 Jabalie (2024111101551527000_69.3.513.5) 2019; 81 Seferovic (2024111101551527000_69.3.513.44) 2019; 221 Zhang (2024111101551527000_69.3.513.27) 2018; 15 2024111101551527000_69.3.513.35 de Goffau (2024111101551527000_69.3.513.45) 2018; 3 2024111101551527000_69.3.513.36 2024111101551527000_69.3.513.11 2024111101551527000_69.3.513.34 2024111101551527000_69.3.513.31 2024111101551527000_69.3.513.10 (2024111101551527000_69.3.513.2) 2019; 133 2024111101551527000_69.3.513.30 2024111101551527000_69.3.513.9 2024111101551527000_69.3.513.19 2024111101551527000_69.3.513.8 2024111101551527000_69.3.513.6 Lv (2024111101551527000_69.3.513.15) 2019; 9 2024111101551527000_69.3.513.18 Eghbal-Fard (2024111101551527000_69.3.513.26) 2019; 234 2024111101551527000_69.3.513.37 2024111101551527000_69.3.513.38 2024111101551527000_69.3.513.3 2024111101551527000_69.3.513.1 Hiippala (2024111101551527000_69.3.513.33) 2018; 10 Liu (2024111101551527000_69.3.513.14) 2017; 36 Kanbay (2024111101551527000_69.3.513.13) 2018; 50 |
| References_xml | – volume: 22 start-page: 434 year: 1999 ident: R19 article-title: The domain-specific probe EUB338 is insufficient for the detection of all bacteria: development and evaluation of a more comprehensive probe set publication-title: Syst Appl Microbiol doi: 10.1016/S0723-2020(99)80053-8 – volume: 14 start-page: 195 year: 2013 ident: R40 article-title: Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-Cadherin/β-Catenin signaling via its FadA adhesin publication-title: Cell Host Microbe doi: 10.1016/j.chom.2013.07.012 – volume: 175 start-page: 189 year: 2004 ident: R6 article-title: Pre-Eclampsia and cardiovascular disease: metabolic syndrome of pregnancy? publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2004.01.038 – volume: 5 year: 2017 ident: R11 article-title: Gut microbiota dysbiosis contributes to the development of hypertension publication-title: Microbiome doi: 10.1186/s40168-016-0222-x – volume: 78 start-page: 670 year: 2007 ident: R37 article-title: Evidence of periopathogenic microorganisms in placentas of women with preeclampsia publication-title: J Periodontol doi: 10.1902/jop.2007.060362 – volume: 572 start-page: 329 year: 2019 ident: R46 article-title: Human placenta has no microbiome but can contain potential pathogens publication-title: Nature doi: 10.1038/s41586-019-1451-5 – volume: 26 start-page: 2460 year: 2010 ident: R20 article-title: Search and clustering orders of magnitude faster than blast publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq461 – volume: 234 start-page: 5106 year: 2019 ident: R26 article-title: The imbalance of Th17/Treg axis involved in the pathogenesis of preeclampsia publication-title: J Cell Physiol doi: 10.1002/jcp.27315 – volume: 359 start-page: 1156 year: 2018 ident: R30 article-title: Translocation of a gut pathobiont drives autoimmunity in mice and humans publication-title: Science doi: 10.1126/science.aar7201 – volume: 132 start-page: 701 year: 2018 ident: R12 article-title: Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure publication-title: Clin Sci doi: 10.1042/CS20180087 – volume: 15 start-page: 382 year: 2018 ident: R34 article-title: The gut microbiota influences anticancer immunosurveillance and general health publication-title: Nat Rev Clin Oncol doi: 10.1038/s41571-018-0006-2 – volume: 41 start-page: 662 year: 2015 ident: R42 article-title: Microbiome of the placenta in pre-eclampsia supports the role of bacteria in the multifactorial cause of pre-eclampsia publication-title: J Obstet Gynaecol Res doi: 10.1111/jog.12619 – volume: 3 start-page: 851 year: 2018 ident: R45 article-title: Recognizing the reagent microbiome publication-title: Nat Microbiol doi: 10.1038/s41564-018-0202-y – volume: 81 year: 2019 ident: R5 article-title: Metabolic syndrome mediates proinflammatory responses of inflammatory cells in preeclampsia publication-title: Am J Reprod Immunol doi: 10.1111/aji.13086 – volume: 54 start-page: 64 year: 2019 ident: R7 article-title: Metabolic syndrome and pre-eclampsia publication-title: Ultrasound Obstet Gynecol doi: 10.1002/uog.20126 – volume: 6 start-page: 610 year: 2012 ident: R21 article-title: An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea publication-title: Isme J doi: 10.1038/ismej.2011.139 – volume: 30 start-page: 268 year: 2015 ident: R36 article-title: Association between specific mucosa-associated microbiota in Crohn's disease at the time of resection and subsequent disease recurrence: a pilot study publication-title: J Gastroenterol Hepatol doi: 10.1111/jgh.12694 – volume: 50 start-page: 1453 year: 2018 ident: R13 article-title: The crosstalk of gut microbiota and chronic kidney disease: role of inflammation, proteinuria, hypertension, and diabetes mellitus publication-title: Int Urol Nephrol doi: 10.1007/s11255-018-1873-2 – volume: 8 start-page: 761 year: 2011 ident: R24 article-title: Bayesian community-wide culture-independent microbial source tracking publication-title: Nat Methods doi: 10.1038/nmeth.1650 10.1038/nmeth.1650 – volume: 66 start-page: 611 year: 2017 ident: R35 article-title: The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls publication-title: Gut doi: 10.1136/gutjnl-2015-310500 – volume: 12 start-page: 223 year: 2008 ident: R43 article-title: Association between maternal infections and preeclampsia: a systematic review of epidemiologic studies publication-title: Matern Child Health J doi: 10.1007/s10995-007-0224-1 – volume: 10 year: 2018 ident: R33 article-title: The potential of gut Commensals in reinforcing intestinal barrier function and alleviating inflammation publication-title: Nutrients doi: 10.3390/nu10080988 – year: 2015 ident: R18 article-title: In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA publication-title: JoVE doi: 10.3791/52836 – volume: 112 start-page: 11060 year: 2015 ident: R38 article-title: Temporal and spatial variation of the human microbiota during pregnancy publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1502875112 – volume: 42 start-page: 1713 year: 2017 ident: R17 article-title: Lanthanum chloride inhibits LPS mediated expressions of pro-inflammatory cytokines and adhesion molecules in HUVECs: involvement of NF-κB-Jmjd3 signaling publication-title: Cell Physiol Biochem doi: 10.1159/000479439 – volume: 387 start-page: 999 year: 2016 ident: R1 article-title: Pre-eclampsia publication-title: Lancet doi: 10.1016/S0140-6736(15)00070-7 – volume: 29 start-page: 1165 year: 2001 ident: R25 article-title: The control of the false discovery rate in multiple testing under dependency publication-title: Ann Statist – volume: 184 start-page: 2260 year: 2014 ident: R29 article-title: Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-γ publication-title: Am J Pathol doi: 10.1016/j.ajpath.2014.05.003 – volume: 221 start-page: 146.e1 year: 2019 ident: R44 article-title: Visualization of microbes by 16S in situ hybridization in term and preterm placentas without intraamniotic infection publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2019.04.036 – volume: 9 year: 2019 ident: R15 article-title: Early-Onset preeclampsia is associated with gut microbial alterations in antepartum and postpartum women publication-title: Front Cell Infect Microbiol doi: 10.3389/fcimb.2019.00224 – volume: 133 start-page: e1 year: 2019 ident: R2 article-title: ACOG practice Bulletin No. 202: gestational hypertension and preeclampsia publication-title: Obstet Gynecol doi: 10.1097/AOG.0000000000003018 – volume: 24 start-page: 1532 year: 2018 ident: R8 article-title: Regional variation limits applications of healthy gut microbiome reference ranges and disease models publication-title: Nat Med doi: 10.1038/s41591-018-0164-x – volume: 19 start-page: 431 year: 2016 ident: R4 article-title: Association of pre-eclampsia with metabolic syndrome and increased risk of cardiovascular disease in women: a systemic review publication-title: Niger J Clin Pract doi: 10.4103/1119-3077.180055 – volume: 36 start-page: 713 year: 2017 ident: R14 article-title: Remodeling of the gut microbiota and structural shifts in preeclampsia patients in South China publication-title: Eur J Clin Microbiol Infect Dis doi: 10.1007/s10096-016-2853-z – volume: 170 start-page: 548 year: 2017 ident: R39 article-title: Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy publication-title: Cell doi: 10.1016/j.cell.2017.07.008 – volume: 150 start-page: 470 year: 2012 ident: R48 article-title: Host remodeling of the gut microbiome and metabolic changes during pregnancy publication-title: Cell doi: 10.1016/j.cell.2012.07.008 – volume: 69 start-page: 1751 year: 2019 ident: R16 article-title: Intestinal microbiota mediates the susceptibility to polymicrobial Sepsis‐Induced liver injury by granisetron generation in mice publication-title: Hepatology doi: 10.1002/hep.30361 – volume: 12 year: 2011 ident: R22 article-title: Metagenomic biomarker discovery and explanation publication-title: Genome Biol doi: 10.1186/gb-2011-12-6-r60 – volume: 6 year: 2018 ident: R23 article-title: Simple statistical identification and removal of contaminant sequences in marker-gene and metagenomics data publication-title: Microbiome doi: 10.1186/s40168-018-0605-2 – volume: 145 start-page: 407 year: 2013 ident: R28 article-title: Tnfr2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis publication-title: Gastroenterology doi: 10.1053/j.gastro.2013.04.011 – volume: 72 start-page: 24 year: 2018 ident: R3 article-title: Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.117.10803 – volume: 22 start-page: 8 year: 2013 ident: R31 article-title: Cytokines as key players in the pathophysiology of preeclampsia publication-title: Med Princ Pract doi: 10.1159/000354200 – volume: 11 start-page: 639 year: 2013 ident: R10 article-title: The gut microbiota and obesity: from correlation to causality publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro3089 – volume: 67 start-page: 1614 year: 2018 ident: R9 article-title: Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus publication-title: Gut doi: 10.1136/gutjnl-2018-315988 – volume: 23 start-page: 141 year: 2015 ident: R41 article-title: Fusobacterium nucleatum: a commensal-turned pathogen publication-title: Curr Opin Microbiol doi: 10.1016/j.mib.2014.11.013 – volume: 50 start-page: 212 year: 2019 ident: R47 article-title: Microbiotas from humans with inflammatory bowel disease alter the balance of gut Th17 and RORγt+ regulatory T cells and exacerbate colitis in mice publication-title: Immunity doi: 10.1016/j.immuni.2018.12.015 – volume: 86 year: 2012 ident: R32 article-title: Heightened pro-inflammatory effect of preeclamptic placental microvesicles on peripheral blood immune cells in Humans1 publication-title: Biol Reprod doi: 10.1095/biolreprod.111.097014 – volume: 15 start-page: 710 year: 2018 ident: R27 article-title: The altered PD-1/PD-L1 pathway delivers the ‘one-two punch’ effects to promote the Treg/Th17 imbalance in pre-eclampsia publication-title: Cell Mol Immunol doi: 10.1038/cmi.2017.70 – volume: 175 start-page: 189 year: 2004 article-title: Pre-Eclampsia and cardiovascular disease: metabolic syndrome of pregnancy? publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2004.01.038 – volume: 72 start-page: 24 year: 2018 article-title: Hypertensive disorders of pregnancy: ISSHP classification, diagnosis, and management recommendations for international practice publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.117.10803 – volume: 12 year: 2011 article-title: Metagenomic biomarker discovery and explanation publication-title: Genome Biol doi: 10.1186/gb-2011-12-6-r60 – volume: 67 start-page: 1614 year: 2018 article-title: Dysbiosis of maternal and neonatal microbiota associated with gestational diabetes mellitus publication-title: Gut doi: 10.1136/gutjnl-2018-315988 – volume: 36 start-page: 713 year: 2017 article-title: Remodeling of the gut microbiota and structural shifts in preeclampsia patients in South China publication-title: Eur J Clin Microbiol Infect Dis doi: 10.1007/s10096-016-2853-z – volume: 66 start-page: 611 year: 2017 article-title: The gut microbial profile in patients with primary sclerosing cholangitis is distinct from patients with ulcerative colitis without biliary disease and healthy controls publication-title: Gut doi: 10.1136/gutjnl-2015-310500 – volume: 6 start-page: 610 year: 2012 article-title: An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea publication-title: Isme J doi: 10.1038/ismej.2011.139 – volume: 23 start-page: 141 year: 2015 article-title: Fusobacterium nucleatum: a commensal-turned pathogen publication-title: Curr Opin Microbiol doi: 10.1016/j.mib.2014.11.013 – volume: 5 year: 2017 article-title: Gut microbiota dysbiosis contributes to the development of hypertension publication-title: Microbiome doi: 10.1186/s40168-016-0222-x – volume: 112 start-page: 11060 year: 2015 article-title: Temporal and spatial variation of the human microbiota during pregnancy publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1502875112 – volume: 22 start-page: 8 year: 2013 article-title: Cytokines as key players in the pathophysiology of preeclampsia publication-title: Med Princ Pract doi: 10.1159/000354200 – volume: 15 start-page: 382 year: 2018 article-title: The gut microbiota influences anticancer immunosurveillance and general health publication-title: Nat Rev Clin Oncol doi: 10.1038/s41571-018-0006-2 – volume: 387 start-page: 999 year: 2016 article-title: Pre-eclampsia publication-title: Lancet doi: 10.1016/S0140-6736(15)00070-7 – volume: 8 start-page: 761 year: 2011 article-title: Bayesian community-wide culture-independent microbial source tracking publication-title: Nat Methods doi: 10.1038/nmeth.1650 10.1038/nmeth.1650 – volume: 11 start-page: 639 year: 2013 article-title: The gut microbiota and obesity: from correlation to causality publication-title: Nat Rev Microbiol doi: 10.1038/nrmicro3089 – volume: 6 year: 2018 article-title: Simple statistical identification and removal of contaminant sequences in marker-gene and metagenomics data publication-title: Microbiome doi: 10.1186/s40168-018-0605-2 – volume: 184 start-page: 2260 year: 2014 article-title: Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-γ publication-title: Am J Pathol doi: 10.1016/j.ajpath.2014.05.003 – year: 2015 article-title: In Situ Detection of Bacteria within Paraffin-embedded Tissues Using a Digoxin-labeled DNA Probe Targeting 16S rRNA publication-title: JoVE doi: 10.3791/52836 – volume: 234 start-page: 5106 year: 2019 article-title: The imbalance of Th17/Treg axis involved in the pathogenesis of preeclampsia publication-title: J Cell Physiol doi: 10.1002/jcp.27315 – volume: 19 start-page: 431 year: 2016 article-title: Association of pre-eclampsia with metabolic syndrome and increased risk of cardiovascular disease in women: a systemic review publication-title: Niger J Clin Pract doi: 10.4103/1119-3077.180055 – volume: 150 start-page: 470 year: 2012 article-title: Host remodeling of the gut microbiome and metabolic changes during pregnancy publication-title: Cell doi: 10.1016/j.cell.2012.07.008 – volume: 69 start-page: 1751 year: 2019 article-title: Intestinal microbiota mediates the susceptibility to polymicrobial Sepsis‐Induced liver injury by granisetron generation in mice publication-title: Hepatology doi: 10.1002/hep.30361 – volume: 26 start-page: 2460 year: 2010 article-title: Search and clustering orders of magnitude faster than blast publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq461 – volume: 14 start-page: 195 year: 2013 article-title: Fusobacterium nucleatum promotes colorectal carcinogenesis by modulating E-Cadherin/β-Catenin signaling via its FadA adhesin publication-title: Cell Host Microbe doi: 10.1016/j.chom.2013.07.012 – volume: 22 start-page: 434 year: 1999 article-title: The domain-specific probe EUB338 is insufficient for the detection of all bacteria: development and evaluation of a more comprehensive probe set publication-title: Syst Appl Microbiol doi: 10.1016/S0723-2020(99)80053-8 – volume: 3 start-page: 851 year: 2018 article-title: Recognizing the reagent microbiome publication-title: Nat Microbiol doi: 10.1038/s41564-018-0202-y – volume: 81 year: 2019 article-title: Metabolic syndrome mediates proinflammatory responses of inflammatory cells in preeclampsia publication-title: Am J Reprod Immunol doi: 10.1111/aji.13086 – volume: 50 start-page: 1453 year: 2018 article-title: The crosstalk of gut microbiota and chronic kidney disease: role of inflammation, proteinuria, hypertension, and diabetes mellitus publication-title: Int Urol Nephrol doi: 10.1007/s11255-018-1873-2 – volume: 15 start-page: 710 year: 2018 article-title: The altered PD-1/PD-L1 pathway delivers the ‘one-two punch’ effects to promote the Treg/Th17 imbalance in pre-eclampsia publication-title: Cell Mol Immunol doi: 10.1038/cmi.2017.70 – volume: 30 start-page: 268 year: 2015 article-title: Association between specific mucosa-associated microbiota in Crohn's disease at the time of resection and subsequent disease recurrence: a pilot study publication-title: J Gastroenterol Hepatol doi: 10.1111/jgh.12694 – volume: 9 year: 2019 article-title: Early-Onset preeclampsia is associated with gut microbial alterations in antepartum and postpartum women publication-title: Front Cell Infect Microbiol doi: 10.3389/fcimb.2019.00224 – volume: 170 start-page: 548 year: 2017 article-title: Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy publication-title: Cell doi: 10.1016/j.cell.2017.07.008 – volume: 572 start-page: 329 year: 2019 article-title: Human placenta has no microbiome but can contain potential pathogens publication-title: Nature doi: 10.1038/s41586-019-1451-5 – volume: 29 start-page: 1165 year: 2001 article-title: The control of the false discovery rate in multiple testing under dependency publication-title: Ann Statist – volume: 133 start-page: e1 year: 2019 article-title: ACOG practice Bulletin No. 202: gestational hypertension and preeclampsia publication-title: Obstet Gynecol doi: 10.1097/AOG.0000000000003018 – volume: 86 year: 2012 article-title: Heightened pro-inflammatory effect of preeclamptic placental microvesicles on peripheral blood immune cells in Humans1 publication-title: Biol Reprod doi: 10.1095/biolreprod.111.097014 – volume: 221 start-page: 146.e1 year: 2019 article-title: Visualization of microbes by 16S in situ hybridization in term and preterm placentas without intraamniotic infection publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2019.04.036 – volume: 359 start-page: 1156 year: 2018 article-title: Translocation of a gut pathobiont drives autoimmunity in mice and humans publication-title: Science doi: 10.1126/science.aar7201 – volume: 145 start-page: 407 year: 2013 article-title: Tnfr2 activates MLCK-dependent tight junction dysregulation to cause apoptosis-mediated barrier loss and experimental colitis publication-title: Gastroenterology doi: 10.1053/j.gastro.2013.04.011 – volume: 78 start-page: 670 year: 2007 article-title: Evidence of periopathogenic microorganisms in placentas of women with preeclampsia publication-title: J Periodontol doi: 10.1902/jop.2007.060362 – volume: 54 start-page: 64 year: 2019 article-title: Metabolic syndrome and pre-eclampsia publication-title: Ultrasound Obstet Gynecol doi: 10.1002/uog.20126 – volume: 42 start-page: 1713 year: 2017 article-title: Lanthanum chloride inhibits LPS mediated expressions of pro-inflammatory cytokines and adhesion molecules in HUVECs: involvement of NF-κB-Jmjd3 signaling publication-title: Cell Physiol Biochem doi: 10.1159/000479439 – volume: 24 start-page: 1532 year: 2018 article-title: Regional variation limits applications of healthy gut microbiome reference ranges and disease models publication-title: Nat Med doi: 10.1038/s41591-018-0164-x – volume: 132 start-page: 701 year: 2018 article-title: Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure publication-title: Clin Sci doi: 10.1042/CS20180087 – volume: 50 start-page: 212 year: 2019 article-title: Microbiotas from humans with inflammatory bowel disease alter the balance of gut Th17 and RORγt+ regulatory T cells and exacerbate colitis in mice publication-title: Immunity doi: 10.1016/j.immuni.2018.12.015 – volume: 41 start-page: 662 year: 2015 article-title: Microbiome of the placenta in pre-eclampsia supports the role of bacteria in the multifactorial cause of pre-eclampsia publication-title: J Obstet Gynaecol Res doi: 10.1111/jog.12619 – volume: 12 start-page: 223 year: 2008 article-title: Association between maternal infections and preeclampsia: a systematic review of epidemiologic studies publication-title: Matern Child Health J doi: 10.1007/s10995-007-0224-1 – volume: 10 year: 2018 article-title: The potential of gut Commensals in reinforcing intestinal barrier function and alleviating inflammation publication-title: Nutrients doi: 10.3390/nu10080988 – volume: 36 start-page: 713 year: 2017 ident: 2024111101551527000_69.3.513.14 article-title: Remodeling of the gut microbiota and structural shifts in preeclampsia patients in South China publication-title: Eur J Clin Microbiol Infect Dis doi: 10.1007/s10096-016-2853-z – volume: 12 year: 2011 ident: 2024111101551527000_69.3.513.22 article-title: Metagenomic biomarker discovery and explanation publication-title: Genome Biol doi: 10.1186/gb-2011-12-6-r60 – volume: 3 start-page: 851 year: 2018 ident: 2024111101551527000_69.3.513.45 article-title: Recognizing the reagent microbiome publication-title: Nat Microbiol doi: 10.1038/s41564-018-0202-y – ident: 2024111101551527000_69.3.513.3 doi: 10.1161/HYPERTENSIONAHA.117.10803 – ident: 2024111101551527000_69.3.513.41 doi: 10.1016/j.mib.2014.11.013 – ident: 2024111101551527000_69.3.513.43 doi: 10.1007/s10995-007-0224-1 – ident: 2024111101551527000_69.3.513.9 doi: 10.1136/gutjnl-2018-315988 – ident: 2024111101551527000_69.3.513.46 doi: 10.1038/s41586-019-1628-y – ident: 2024111101551527000_69.3.513.42 doi: 10.1111/jog.12619 – ident: 2024111101551527000_69.3.513.23 doi: 10.1186/s40168-018-0605-2 – ident: 2024111101551527000_69.3.513.10 doi: 10.1038/nrmicro3089 – volume: 132 start-page: 701 year: 2018 ident: 2024111101551527000_69.3.513.12 article-title: Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure publication-title: Clin Sci doi: 10.1042/CS20180087 – volume: 42 start-page: 1713 year: 2017 ident: 2024111101551527000_69.3.513.17 article-title: Lanthanum chloride inhibits LPS mediated expressions of pro-inflammatory cytokines and adhesion molecules in HUVECs: involvement of NF-κB-Jmjd3 signaling publication-title: Cell Physiol Biochem doi: 10.1159/000479439 – ident: 2024111101551527000_69.3.513.24 doi: 10.1038/nmeth.1650 – ident: 2024111101551527000_69.3.513.36 doi: 10.1111/jgh.12694 – volume: 81 year: 2019 ident: 2024111101551527000_69.3.513.5 article-title: Metabolic syndrome mediates proinflammatory responses of inflammatory cells in preeclampsia publication-title: Am J Reprod Immunol doi: 10.1111/aji.13086 – ident: 2024111101551527000_69.3.513.6 doi: 10.1016/j.atherosclerosis.2004.01.038 – volume: 15 start-page: 710 year: 2018 ident: 2024111101551527000_69.3.513.27 article-title: The altered PD-1/PD-L1 pathway delivers the ‘one-two punch’ effects to promote the Treg/Th17 imbalance in pre-eclampsia publication-title: Cell Mol Immunol doi: 10.1038/cmi.2017.70 – ident: 2024111101551527000_69.3.513.25 doi: 10.1214/aos/1013699998 – ident: 2024111101551527000_69.3.513.8 doi: 10.1038/s41591-018-0164-x – volume: 69 start-page: 1751 year: 2019 ident: 2024111101551527000_69.3.513.16 article-title: Intestinal microbiota mediates the susceptibility to polymicrobial Sepsis‐Induced liver injury by granisetron generation in mice publication-title: Hepatology doi: 10.1002/hep.30361 – volume: 19 start-page: 431 year: 2016 ident: 2024111101551527000_69.3.513.4 article-title: Association of pre-eclampsia with metabolic syndrome and increased risk of cardiovascular disease in women: a systemic review publication-title: Niger J Clin Pract doi: 10.4103/1119-3077.180055 – volume: 170 start-page: 548 year: 2017 ident: 2024111101551527000_69.3.513.39 article-title: Fusobacterium nucleatum promotes chemoresistance to colorectal cancer by modulating autophagy publication-title: Cell doi: 10.1016/j.cell.2017.07.008 – ident: 2024111101551527000_69.3.513.48 doi: 10.1016/j.cell.2012.07.008 – ident: 2024111101551527000_69.3.513.11 doi: 10.1186/s40168-016-0222-x – ident: 2024111101551527000_69.3.513.31 doi: 10.1159/000354200 – ident: 2024111101551527000_69.3.513.18 doi: 10.3791/52836 – volume: 234 start-page: 5106 year: 2019 ident: 2024111101551527000_69.3.513.26 article-title: The imbalance of Th17/Treg axis involved in the pathogenesis of preeclampsia publication-title: J Cell Physiol doi: 10.1002/jcp.27315 – ident: 2024111101551527000_69.3.513.40 doi: 10.1016/j.chom.2013.07.012 – ident: 2024111101551527000_69.3.513.28 doi: 10.1053/j.gastro.2013.04.011 – volume: 133 start-page: e1 year: 2019 ident: 2024111101551527000_69.3.513.2 article-title: ACOG practice Bulletin No. 202: gestational hypertension and preeclampsia publication-title: Obstet Gynecol – ident: 2024111101551527000_69.3.513.34 doi: 10.1038/s41571-018-0006-2 – ident: 2024111101551527000_69.3.513.1 doi: 10.1016/S0140-6736(15)00070-7 – ident: 2024111101551527000_69.3.513.35 doi: 10.1136/gutjnl-2015-310500 – volume: 10 year: 2018 ident: 2024111101551527000_69.3.513.33 article-title: The potential of gut Commensals in reinforcing intestinal barrier function and alleviating inflammation publication-title: Nutrients doi: 10.3390/nu10080988 – ident: 2024111101551527000_69.3.513.37 doi: 10.1902/jop.2007.060362 – ident: 2024111101551527000_69.3.513.29 doi: 10.1016/j.ajpath.2014.05.003 – ident: 2024111101551527000_69.3.513.20 doi: 10.1093/bioinformatics/btq461 – ident: 2024111101551527000_69.3.513.30 doi: 10.1126/science.aar7201 – ident: 2024111101551527000_69.3.513.38 doi: 10.1073/pnas.1502875112 – volume: 54 start-page: 64 year: 2019 ident: 2024111101551527000_69.3.513.7 article-title: Metabolic syndrome and pre-eclampsia publication-title: Ultrasound Obstet Gynecol doi: 10.1002/uog.20126 – volume: 50 start-page: 1453 year: 2018 ident: 2024111101551527000_69.3.513.13 article-title: The crosstalk of gut microbiota and chronic kidney disease: role of inflammation, proteinuria, hypertension, and diabetes mellitus publication-title: Int Urol Nephrol doi: 10.1007/s11255-018-1873-2 – ident: 2024111101551527000_69.3.513.21 doi: 10.1038/ismej.2011.139 – volume: 9 year: 2019 ident: 2024111101551527000_69.3.513.15 article-title: Early-Onset preeclampsia is associated with gut microbial alterations in antepartum and postpartum women publication-title: Front Cell Infect Microbiol doi: 10.3389/fcimb.2019.00224 – ident: 2024111101551527000_69.3.513.19 doi: 10.1016/S0723-2020(99)80053-8 – ident: 2024111101551527000_69.3.513.47 doi: 10.1016/j.immuni.2018.12.015 – volume: 86 year: 2012 ident: 2024111101551527000_69.3.513.32 article-title: Heightened pro-inflammatory effect of preeclamptic placental microvesicles on peripheral blood immune cells in Humans1 publication-title: Biol Reprod doi: 10.1095/biolreprod.111.097014 – volume: 221 start-page: 146.e1 year: 2019 ident: 2024111101551527000_69.3.513.44 article-title: Visualization of microbes by 16S in situ hybridization in term and preterm placentas without intraamniotic infection publication-title: Am J Obstet Gynecol doi: 10.1016/j.ajog.2019.04.036 |
| SSID | ssj0008891 |
| Score | 2.6634915 |
| Snippet | ObjectivePre-eclampsia (PE) is one of the malignant metabolic diseases that complicate pregnancy. Gut dysbiosis has been identified for causing metabolic... Pre-eclampsia (PE) is one of the malignant metabolic diseases that complicate pregnancy. Gut dysbiosis has been identified for causing metabolic diseases, but... |
| SourceID | proquest pubmed crossref bmj |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 513 |
| SubjectTerms | Animals Antibiotics Antigens Bacteria Bacterial Translocation Blood Pressure Case-Control Studies CD4 Lymphocyte Count Chemokines - genetics Creatinine Creatinine - blood Cytokines - genetics Digestive system Discriminant analysis Disease Disease Models, Animal Dysbacteriosis Dysbiosis - complications Dysbiosis - physiopathology Embryos Faecalibacterium Feces - microbiology Female Fetal Resorption - microbiology Fetuses Flow cytometry Fusobacteria Fusobacterium Gastrointestinal Microbiome Gastrointestinal tract Gene expression Gestation Gut microbiota Gynecology Hospitals Humans Hybridization Hypertension Immune response Immunoglobulins immunology Inflammation Insulin resistance intestinal bacteria intestinal barrier function Intestinal microflora Intestine, Small - immunology Metabolic disorders Metabolic syndrome Mice Microbiomes Microbiota Obstetrics Opportunist infection Pathogenesis Placenta Placenta - immunology Placenta - metabolism Placenta - microbiology Pre-eclampsia Pre-Eclampsia - microbiology Pre-Eclampsia - physiopathology Preeclampsia Pregnancy Probiotics Proteins Proteinuria Proteinuria - urine RNA, Messenger - metabolism rRNA 16S Small intestine Spleen Statistical analysis Studies T-Lymphocytes, Regulatory Taxonomy Th17 Cells Transplantation Urine Veillonella |
| SummonAdditionalLinks | – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1LT8MwDI5gSIgL4s1goCAhOKCKtU3T5oQQYkxI48TQblXTpGjTaAdtD_x77DbtxIGJc_OobMefHTs2IZe67yTClZ7FAjvCqxvPEv3EtkQkHHDGVJ9pfDs8euHDMXueeBNz4ZabtMpGJ1aKWmUx3pHfOpWlAGDN7xafFnaNwuiqaaGxTjawdBlKtT9pHS7M4LEbTez5TDSPZlx--14Ws3QOMmILUEOAmTaAi_yY_YanP2zOCnsGO2TbGI30vubyLlnT6R7ZHJmw-D55eyoLqr5zOc3yaU7BzQaG5RRsO6qWSUE0SygmfegYpGCRTyNqmvRQWZdshi0KhC7EN-TXARkPHl8fhpZpmGBJzw4KS_laS-mLhAs_VlqxWII5FijRBz7xBJyXSAQcPKxYqoAJN1GO9GMNXnAMtPWEe0g6aZbqY0IjrBvIEq7h_CLGB4GSAO_S05zZEdNdcg3UCo3A52HlS7g8rOkaIl3Dmq5dcoUjF3XxjJUD7Yb0YWwKlGOfjPnKOTftnP_s0Gs4uvzzpWB1yUX7GQ4ZRk6iVGcljnFdjpVxYImjWhLa7WDpKlx7snrxU7LloKtepa_1SKf4KvUZ2DOFPK-E9gd_XPBI priority: 102 providerName: ProQuest |
| Title | Gut dysbiosis induces the development of pre-eclampsia through bacterial translocation |
| URI | https://gut.bmj.com/content/69/3/513.full https://www.ncbi.nlm.nih.gov/pubmed/31900289 https://www.proquest.com/docview/2352266236 https://www.proquest.com/docview/2333605261 |
| Volume | 69 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV3dS8MwED90gvgifjudI4Log9StTZo2jyp-IExEVOZTaZpUNrQT2z3433vXj4kPik8tNMmVu0vud0nuDuDA9r1Uce07InRj2rrxHdVPXUfFykNnzPSFpdjhwa28fhQ3Q39YJ4umWJiXaXGi38ZVNAPlZ8qKnlQ93vNdfkI70vOwQDVJSIHV88Ns0Q2b4ni46PqBUE18DJc05Dh7RXVwFa44aB6pOgy-lIdsaFKQ3E-j9AvSLC3O5Qos11CRnVayXYU5m63B4qA-DF-Hp6tpwcxnrkeTfJQzdK5RTDlDRMfM91UgNkkZXfWwCcr-PR_FrC7Nw3SVqBlJFGSwyKqRlDbg8fLi4fzaqcskONp3w8IxgbVaByqVKkiMNSLRCMJCo_ooHZmiyxKrUKJflWgTCsVT4-kgsej7Joi9fMU3oZVNMrsNLKZsgSKVFmctWfYwNBqNuvatFG4sbBuOkFtRreZ5VHoQXEYViyNicVSxuA2H1PK9SpnxZ0O3YX2U1GnJqTrG6599jmd9_kOh00j0-8-9Engi9pNt2J99xqlF5yVxZidTasO5pHw4OMRWpQkzco3-7PybI7uw5JGvXt5f60Cr-JjaPQQ0he7CfDAMuqVCd2Hh9HwweMLn2cXt3f0XV4Hwvw |
| linkProvider | BMJ Publishing Group Ltd |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LT9wwEB4hKhUuqC2vpZQaqcABRZuH48SHCiFaWArLCdDeQhw7aBEkS5MV4k_xGzuTx656YMWFcxw7GX-e-cYezwD8MLabSk_5Fg-dmLZufEvaqWPJWLrojGmbG7o73L8QvSv-Z-AP5uClvQtDYZWtTqwUtc4T2iPvuhVTQGMtDkaPFlWNotPVtoRGDYsz8_yELlvx8_QXzu-O6x7_vjzqWU1VAUv5TlhaOjBGqUCmQgaJNponCjlLqKWNPyNSZPixDAW6IYnSIZdeql0VJAZdxQQ_wKfkS6jyP6DhtcnZCwYTB48ihpxW8_sBl-0lHU90b8flXXaPmHQkqj200Q4aM_Vw9785fIXjVrbu-BMsNSSVHdao-gxzJvsCH_vNMfwyXJ-MS6afCzXMi2HB0K1HgBQMuSTT0yAklqeMgkxMgqgbFcOYNUWBmKpTROMQJZlKsqeEjxW4ehdRrsJ8lmdmHVhMeQp5KgzqC-IUYagV0gnlG8GdmJsO7KG0omaBFVHlu3giquUakVyjWq4d2KWWozpZx8yGTiv6KGkSolNdjvuZ7-xP3nnLCJvtjE6_fArkDmxPHuOippOaODP5mNp4nqBMPNjFWo2EyXDYdXU8vDG78--w0Lvsn0fnpxdnX2HRpW2CKnRuE-bLv2PzDblUqbYqADO4ee8V8w-FdC6W |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LT9wwEB6hRUJcEJQCy9OVWjigiE3iOPEBoRbYQikrhABxC3HsoEWQbJusEH-NX9eZPHbFoSsunOPYyfjzzDf2eAbgq-k4iXSVZ_HAjmjrxrNkJ7EtGUkHnTHd4YbuDp_3xMk1_3Xr3U7Ba3MXhsIqG51YKmqdxbRHvueUTAGNtdhL6rCIi6PuweCPRRWk6KS1KadRQeTMvDyj-5bvnx7hXH9znO7x1eGJVVcYsJRnB4WlfWOU8mUipB9ro3mskL8EWnbwx0SCbD-SgUCXJFY64NJNtKP82KDbGOPHeJSICdX_tE9eUQumfxz3Li5HdiBo6vWhHfB8LpsrO_gH98PiIX1EhNoSlSBabBtNm3p6eGsc_8N4S8vXnYe5mrKy7xXGFmDKpJ9g5rw-lF-Em5_DgumXXPWzvJ8zdPIRLjlDZsn0OCSJZQmjkBMTIwYHeT9idYkgpqqE0ThEQYaTrCuh5TNcf4gwl6CVZqlZARZR1kKeCIPagxhGEGiF5EJ5RnA74qYNOyitsF5ueVh6Mq4IK7mGJNewkmsbtqnloErdMbGh3Yg-jOv06FSl43HiO7ujd94zwnozo-MvH8O6DV9Gj3GJ07lNlJpsSG1cV1BeHuxiuULCaDjsujwsXp3c-RbM4GoJf5_2ztZg1qE9gzKObh1axd-h2UBiVajNGsEM7j560fwD1aM0MQ |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Gut+dysbiosis+induces+the+development+of+pre-eclampsia+through+bacterial+translocation&rft.jtitle=Gut&rft.au=Chen%2C+Xia&rft.au=Li%2C+Pan&rft.au=Liu%2C+Mian&rft.au=Zheng%2C+Huimin&rft.date=2020-03-01&rft.pub=BMJ+Publishing+Group+Ltd+and+British+Society+of+Gastroenterology&rft.issn=0017-5749&rft.eissn=1468-3288&rft.volume=69&rft.issue=3&rft.spage=513&rft.epage=522&rft_id=info:doi/10.1136%2Fgutjnl-2019-319101&rft_id=info%3Apmid%2F31900289&rft.externalDBID=gut&rft.externalDocID=gutjnl |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0017-5749&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0017-5749&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0017-5749&client=summon |