Functional characterization of the ER stress induced X-box-binding protein-1 (Xbp-1) in the porcine system

• Published in: BMC molecular biology Vol. 12; no. 1; p. 25
• Main Authors: Zhang, Jin-Yu, Lee, Kyu-Sun, Kim, Ji-Su, Song, Bong-Seok, Jin, Dong-Il, Koo, Deog-Bon, Yu, Kweon
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 24.05.2011; BioMed Central
• Subjects: Amino Acid Sequence; Animals; Cell Death; Cells, Cultured; Cloning, Molecular; DNA-Binding Proteins - analysis; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Endoplasmic reticulum; Endoplasmic Reticulum - metabolism; Fibroblasts - drug effects; Gene expression; Gene Knockdown Techniques; Messenger RNA; Molecular Sequence Data; Physiological aspects; Regulatory Factor X Transcription Factors; RNA Splicing; RNA, Messenger - genetics; Swine - metabolism; Transcription Factors - analysis; Transcription Factors - genetics; Transcription Factors - metabolism; Tunicamycin - pharmacology; Unfolded Protein Response - drug effects; South Korea
• ISSN: 1471-2199; 1471-2199
• DOI: 10.1186/1471-2199-12-25

The unfolded protein response (UPR) is an evolutionary conserved adaptive reaction for increasing cell survival under endoplasmic reticulum (ER) stress conditions. X-box-binding protein-1 (Xbp1) is a key transcription factor of UPR that activates genes involved in protein folding, secretion, and deg...