Tfh cells with NLRP3 inflammasome activation are essential for high-affinity antibody generation, germinal centre formation and autoimmunity

• Published in: Annals of the rheumatic diseases Vol. 81; no. 7; pp. 1006 - 1012
• Main Authors: Zhao, Zhenhuan, Xu, Bihua, Wang, Shuang, Zhou, Mianjing, Huang, Yuefang, Guo, Chaohuan, Li, Mengyuan, Zhao, Jijun, Sung, Sun-Sang J, Gaskin, Felicia, Yang, Niansheng, Fu, Shu Man
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and European League Against Rheumatism 01.07.2022; Elsevier Limited
• Subjects: Affinity; Animals; Antigens; Autoantibodies; Autoimmunity; Blood; Caspase-1; Cell activation; Cell differentiation; Clonal deletion; Erythrocytes; Germinal Center; Germinal centers; Immune response (humoral); Immunization; Inflammasomes; Inflammasomes - metabolism; Inflammation; Laboratory animals; Lupus; Lupus Erythematosus, Systemic; Lymphatic system; Lymphocytes; Lymphocytes B; Lymphocytes T; Mice; Mice, Inbred MRL lpr; NLR Family, Pyrin Domain-Containing 3 Protein - immunology; Pathogenesis; Phenotypes; Population; Statistical analysis; Systemic lupus erythematosus; T Follicular Helper Cells - immunology; T-Lymphocyte subsets; T-Lymphocytes, Helper-Inducer; Autoimmunity; T-Lymphocyte subsets; Inflammation; Autoantibodies; Lupus Erythematosus, Systemic

ObjectiveNLRP3 inflammasome regulates T cell responses. This study examined the roles of NLRP3 inflammasome activation in the regulation of T follicular helper (Tfh) cells during humoral response to T dependent antigens and in systemic lupus erythematosus (SLE).MethodsNLRP3 inflammasome activation o...