Tfh cells with NLRP3 inflammasome activation are essential for high-affinity antibody generation, germinal centre formation and autoimmunity - Zhao, Zhenhuan; Xu, Bihua; Wang, Shuang; Zhou, Mianjing; Huang, Yuefang; Guo, Chaohuan; Li, Mengyuan; Zhao, Jijun; Sung, Sun-Sang J; Gaskin, Felicia; Yang, Niansheng; Fu, Shu Man (Annals of the rheumatic diseases, 2022)
Keywords: Affinity; Animals; Antigens; Autoantibodies; Autoimmunity; Blood; Caspase-1; Cell activation; Cell differentiation; Clonal deletion; Erythrocytes; Germinal Center; Germinal centers; Immune response (humoral); Immunization; Inflammasomes; Inflammasomes - metabolism; Inflammation; Laboratory animals; Lupus; Lupus Erythematosus, Systemic; Lymphatic system; Lymphocytes; Lymphocytes B; Lymphocytes T; Mice; Mice, Inbred MRL lpr; NLR Family, Pyrin Domain-Containing 3 Protein - immunology; Pathogenesis; Phenotypes; Population; Statistical analysis; Systemic lupus erythematosus; T Follicular Helper Cells - immunology; T-Lymphocyte subsets; T-Lymphocytes, Helper-Inducer; Autoimmunity; T-Lymphocyte subsets; Inflammation; Autoantibodies; Lupus Erythematosus, Systemic