Tissue-specific cytokine release from human extra-placental membranes stimulated by lipopolysaccharide in a two-compartment tissue culture system

• Published in: Reproductive biology and endocrinology Vol. 7; no. 1; p. 117
• Main Authors: Thiex, Natalie W, Chames, Mark C, Loch-Caruso, Rita K
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 26.10.2009; BioMed Central; BMC
• Subjects: Cells, Cultured; Cytokines - secretion; Decidua - drug effects; Decidua - secretion; Extraembryonic Membranes - drug effects; Extraembryonic Membranes - secretion; Female; Humans; Inflammation Mediators - metabolism; Lipopolysaccharides - pharmacology; Organ Specificity - drug effects; Pregnancy; Tissue Culture Techniques - instrumentation; Tissue Culture Techniques - methods

The extra-placental gestational membranes secrete cytokines in response to bacteria and other infectious agents, with potentially adverse consequences for pregnancy. The present study used lipopolysaccharide (LPS) as a prototype endotoxin to investigate the pattern of stimulated cytokine release fro...