Lactate dehydrogenase as a biomarker for silica exposure-induced toxicity in agate workers

• Published in: Occupational and environmental medicine (London, England) Vol. 71; no. 8; pp. 578 - 582
• Main Author: Aggarwal, Bhagwan Das
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group 01.08.2014; BMJ Publishing Group LTD
• Subjects: Adult; Biological and medical sciences; Biomarkers - blood; Blood; Blood cells; Blood plasma; Cytotoxicity; Dehydrogenase; Dehydrogenases; Dust; Enzymes; Exposure; Exposure assessment; Extraction and Processing Industry; Female; Grinding; Humans; Informed consent; L-Lactate Dehydrogenase - blood; Lactate dehydrogenase; Lactates; Lung diseases; Male; Medical sciences; Middle Aged; Occupational Diseases - blood; Occupational Diseases - etiology; Occupational exposure; Occupational Exposure - adverse effects; Occupational medicine; Oxidation; Particulate Matter - adverse effects; Plasma; Public health. Hygiene-occupational medicine; Silica; Silica dust; Silicon dioxide; Silicon Dioxide - adverse effects; Silicosis; Silicosis - blood; Silicosis - etiology; Sodium; Statistical results; Toxicity; Tuberculosis; Workers; Young Adult; Asia; India; United States > US; Human; Gemstone; Enzyme; Toxicity; Biological marker; Worker; Oxidoreductases; Occupational exposure; Silica; L-Lactate dehydrogenase; Occupational medicine; Inorganic compound; Lactate Dehydrogenase; Agate Workers; Biomarker; Silica-Exposure; Cyto-Toxicity

Objectives Agate workers are chronically exposed to silica dust generated from agate grinding, which makes them susceptible to silicosis. In the absence of diagnosis at an early stage, the workers continue to be exposed to silica dust until the development of silicosis. The present study was underta...