Genes related to emphysema are enriched for ubiquitination pathways

• Published in: BMC pulmonary medicine Vol. 14; no. 1; p. 187
• Main Authors: Stepaniants, Sergey, Wang, I-Ming, Boie, Yves, Mortimer, James, Kennedy, Brian, Elliott, Mark, Hayashi, Shizu, Luo, Honglin, Wong, Jerry, Loy, Leanna, Coulter, Silvija, Roberts, Christopher J, Hogg, James C, Sin, Don D, O’Neill, Gary, Crackower, Michael, Morris, Melody, Paré, Peter D, Obeidat, Ma’en
• Format: Journal Article
• Language: English
• Published: England BioMed Central 29.11.2014; BioMed Central Ltd
• Subjects: Aged; Chronic obstructive pulmonary disease; DNA-Binding Proteins - metabolism; Down-Regulation; Emphysema; F-Box Proteins - metabolism; Female; Gene Expression; Humans; Laboratories; Lung - pathology; Lung Volume Measurements; Lungs; Male; Medical research; Middle Aged; Organ Size - genetics; Patients; Proteins; Pulmonary Alveoli - pathology; Pulmonary Emphysema - genetics; Pulmonary Emphysema - metabolism; Pulmonology; Signal Transduction - genetics; Smoking - physiopathology; Statistical analysis; Studies; Ubiquitin - metabolism; Ubiquitin-Specific Proteases - metabolism; Ubiquitination - genetics; Up-Regulation

Increased small airway resistance and decreased lung elasticity contribute to the airflow limitation in chronic obstructive pulmonary disease (COPD). The lesion that corresponds to loss of lung elasticity is emphysema; the small airway obstruction is due to inflammatory narrowing and obliteration. D...