Effect of pregnancy on moderate renal failure in reflux nephropathy

• Published in: British Medical Journal (Clinical research ed.) Vol. 292; no. 6523; pp. 796 - 798
• Main Authors: Becker, G J, Ihle, B U, Fairley, K F, Bastos, M, Kincaid-Smith, P
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 22.03.1986; British Medical Association; BMJ Publishing Group LTD
• Subjects: Adult; Blood plasma; Blood Pressure; Creatinine - blood; Female; Follow-Up Studies; Glomerulonephritis - physiopathology; Humans; Hypertension; Hypertension - physiopathology; IgA glomerulonephritis; Kidney diseases; Kidney Diseases - complications; Kidney Diseases - physiopathology; Kidney failure; Kidney Failure, Chronic - physiopathology; Kidneys; Lesions; Pregnancy; Pregnancy Complications - physiopathology; Pregnancy, Prolonged; Proteinuria - complications; Renal function

During a 10 year study of women with reflux nephropathy 20 women had plasma creatinine concentrations in the range 0.2-0.4 mmol/l (2.3-4.5 mg/100 ml). Six experienced pregnancies exceeding 12 weeks' gestation. Pregnancy was associated with rapid deterioration in function in all six, resulting i...