Therapeutic Drug Monitoring in the Management of HIV-Infected Patients

• Published in: Current medicinal chemistry Vol. 15; no. 19; pp. 1925 - 1939
• Main Authors: JELENA, Ivanovic, EMANUELE, Nicastri, PAOLO, Ascenzi, RITA, Bellagamba, MARINIS ELISABETTA, De, STEFANIA, Notari, LEOPOLDO PAOLO, Pucillo, VALERIO, Tozzi, GIUSEPPE, Ippolito, PASQUALE, Narciso
• Format: Journal Article
• Language: English
• Published: Schiphol Bentham Science Publishers Ltd 01.08.2008; Bentham Science
• Subjects: Anti-HIV Agents - chemistry; Anti-HIV Agents - pharmacokinetics; Anti-HIV Agents - therapeutic use; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antiviral agents; Biological and medical sciences; Chromatography, High Pressure Liquid; Clinical Trials as Topic; Drug Interactions; Drug Monitoring; HIV Infections - blood; HIV Infections - drug therapy; HIV-1 - drug effects; Human immunodeficiency virus; Human viral diseases; Humans; Immunoenzyme Techniques; Infectious diseases; Mass Spectrometry; Medical sciences; Pharmacology. Drug treatments; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Human; Immunopathology; Antiretroviral agent; Pharmacogenetics; Retroviridae; Patient; AIDS; Review; Immune deficiency; Lentivirus; Infection; Virus; Therapeutic drug monitoring; Analysis method; HIV; Viral disease; genotypic inhibitory quotient; Antiviral; anti-retroviral therapy; Human immunodeficiency virus; Pharmacokinetics; Pharmacogenomics

The rate of HIV-positive patients that fails to reach or to maintain a durable virological suppression under anti-retroviral (ARV) therapy might be as high as 50%, therefore new tools to improve ARV drug efficacy are urgently needed. Among others, therapeutic drug monitoring (TDM) is a strategy by w...