Microglial phagocytosis induced by fibrillar β-amyloid is attenuated by oligomeric β-amyloid: implications for Alzheimer's disease

• Published in: Molecular neurodegeneration Vol. 6; no. 1; p. 45
• Main Authors: Pan, Xiao-dong, Zhu, Yuan-gui, Lin, Nan, Zhang, Jing, Ye, Qin-yong, Huang, Hua-pin, Chen, Xiao-chun
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 30.06.2011; BioMed Central; BMC

Reactive microglia are associated with β-amyloid (Aβ) deposit and clearance in Alzhiemer's Disease (AD). Paradoxically, entocranial resident microglia fail to trigger an effective phagocytic response to clear Aβ deposits although they mainly exist in an "activated" state. Oligomeric A...