Pharmacological heterogeneity limits antidepressant study

A third study used lofepramine as a comparitor, a more modern tricyclic with a much more benign anticholinergic side effect profile than its older cousins, which have an adverse event rate similar to the selective serotonin reuptake inhibitors. 2 Two of the three studies providing unambiguous data f...

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Published inBMJ Vol. 327; no. 7409; p. 289
Main Author Hale, Anthony S
Format Journal Article
LanguageEnglish
Published England British Medical Association 02.08.2003
BMJ Publishing Group LTD
BMJ Publishing Group
BMJ Publishing Group Ltd
EditionInternational edition
Subjects
Amitriptyline - therapeutic use
Antidepressants
Antidepressive Agents - therapeutic use
Depressive Disorder - drug therapy
Depressive disorders
Humans
Letters
Mianserin - therapeutic use
Paroxetine - therapeutic use
Pharmacology
Reuptake
Serotonin
Serotonin agents
Serotonin Uptake Inhibitors - therapeutic use
Studies
Online AccessGet full text

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Abstract A third study used lofepramine as a comparitor, a more modern tricyclic with a much more benign anticholinergic side effect profile than its older cousins, which have an adverse event rate similar to the selective serotonin reuptake inhibitors. 2 Two of the three studies providing unambiguous data for the efficacy analysis were of paroxetine against amitriptyline.
AbstractList A third study used lofepramine as a comparitor, a more modern tricyclic with a much more benign anticholinergic side effect profile than its older cousins, which have an adverse event rate similar to the selective serotonin reuptake inhibitors. 2 Two of the three studies providing unambiguous data for the efficacy analysis were of paroxetine against amitriptyline.
Author Hale, Anthony S
AuthorAffiliation University of Kent, Canterbury CT2 7NZ A.S.Hale@ukc.ac.uk
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MacGillivray, Arroll, Hatcher, Ogston, Reid, Sullivan 2003; 326
7894881 - Br J Psychiatry. 1995 Jan;166(1):80-6
12742924 - BMJ. 2003 May 10;326(7397):1014
References_xml – volume: 326
  start-page: 1014
  year: 2003
  article-title: Efficacy and tolerability of selective serotonin reuptake inhibitors compared with tricyclic antidepressants in depression treated in primary care: systematic review and meta-analysis.
  publication-title: BMJ
  contributor:
    fullname: Sullivan
– volume: 166
  start-page: 80
  year: 1995
  article-title: Placebo-controlled trial of lithium augmentation of fluoxetine and lofepramine.
  publication-title: Br J Psychiatry
  contributor:
    fullname: Lock
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SubjectTerms Amitriptyline - therapeutic use
Antidepressants
Antidepressive Agents - therapeutic use
Depressive Disorder - drug therapy
Depressive disorders
Humans
Letters
Mianserin - therapeutic use
Paroxetine - therapeutic use
Pharmacology
Reuptake
Serotonin
Serotonin agents
Serotonin Uptake Inhibitors - therapeutic use
Studies
Title Pharmacological heterogeneity limits antidepressant study
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