Compounds Combining Aminoadamantane and Monoterpene Moieties: Cytotoxicity and Mutagenic Effects

• Published in: Medicinal chemistry (Shp-sariqah, United Arab Emirates) Vol. 11; no. 7; p. 629
• Main Authors: Suslov, Evgeniy V, Ponomarev, Konstantin Yu, Rogachev, Artem D, Pokrovsky, Michail A, Pokrovsky, Andrey G, Pykhtina, Maria B, Beklemishev, Anatoly B, Korchagina, Dina V, Volcho, Konstantin P, Salakhutdinov, Nariman F
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2015
• Subjects: Adamantane - chemistry; Adamantane - pharmacology; Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Cell Line, Tumor; Dogs; Humans; Madin Darby Canine Kidney Cells; Monoterpenes - chemistry; Mutagens - chemistry; Mutagens - pharmacology

A series of secondary amines combining monoterpenoid and aminoadamantane moieties have been synthesized. Their cytotoxic activity against human cancer cells CEM-13, MT-4, and U-937 has been studied for the first time. Most of the obtained compounds exhibited a significant cytotoxic activity with the...