Autoregulation of the gonadotropin-releasing hormone (GnRH) system during puberty: effects of antagonistic versus agonistic GnRH analogs in a female rat model

• Published in: Journal of endocrinology Vol. 169; no. 2; pp. 361 - 371
• Main Authors: Roth, C, Schricker, M, Lakomek, M, Strege, A, Heiden, I, Luft, H, Munzel, U, Wuttke, W, Jarry, H
• Format: Journal Article
• Language: English
• Published: Colchester BioScientifica 01.05.2001; Portland Press
• Subjects: Analysis of Variance; Animals; Autocrine Communication; Biological and medical sciences; Dose-Response Relationship, Drug; Estradiol - blood; Female; Follicle Stimulating Hormone - blood; Fundamental and applied biological sciences. Psychology; Gene Expression - drug effects; Gonadotropin-Releasing Hormone - agonists; Gonadotropin-Releasing Hormone - analogs & derivatives; Gonadotropin-Releasing Hormone - antagonists & inhibitors; Gonadotropin-Releasing Hormone - genetics; Gonadotropin-Releasing Hormone - pharmacology; Homeostasis; Hormone metabolism and regulation; Humans; Hypothalamus - metabolism; Luteinizing Hormone - blood; Mammalian female genital system; Models, Animal; Ovary - metabolism; Pituitary Gland - metabolism; Puberty, Precocious - drug therapy; Rats; Rats, Sprague-Dawley; Receptors, LHRH - genetics; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - analysis; Sexual Maturation - physiology; Stimulation, Chemical; Triptorelin Pamoate - pharmacology; Uterus - metabolism; Vertebrates: reproduction; Puberty; Rat; Rodentia; Central nervous system; Gonadotropin RH; Hypothalamus; Gene expression; Hypothalamic hormone; Ovary; Vertebrata; Mammalia; Female genital system; Self regulation; Hormone releasing factor; Brain (vertebrata); Hormonal receptor

To address whether gonadotropin-releasing hormone (GnRH) regulates its own expression and the expression of its receptor in the hypothalamus and ovary, we treated five groups of prepubertal/peripubertal female rats from postnatal days 25-36 with either the GnRH agonist triptorelin (TRIP) or the GnRH...