Atrophy of the corpus callosum associated with a decrease in cortical benzodiazepine receptor in large cerebral arterial occlusive diseases

• Published in: Journal of neurology, neurosurgery and psychiatry Vol. 68; no. 3; pp. 317 - 322
• Main Authors: Yamauchi, H, Fukuyama, H, Dong, Y, Nabatame, H, Nagahama, Y, Nishizawa, S, Konishi, J, Shio, H
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.03.2000; BMJ; BMJ Publishing Group LTD; BMJ Group
• Subjects: Aged; Arterial Occlusive Diseases - diagnostic imaging; Arterial Occlusive Diseases - pathology; Atrophy; Atrophy - diagnostic imaging; Atrophy - pathology; benzodiazepine receptors; Benzodiazepines; Biological and medical sciences; Brain - diagnostic imaging; Brain - pathology; carotid artery disease; cerebrovascular disorders; corpus callosum; Corpus Callosum - diagnostic imaging; Corpus Callosum - pathology; Diabetes; Disease; Humans; Hypertension; Ischemia; Magnetic Resonance Imaging; Medical imaging; Medical sciences; Metabolism; Middle Aged; Morphology; Neurology; Patients; Receptors, GABA-A - metabolism; Tomography, Emission-Computed; Tomography, Emission-Computed, Single-Photon; Vascular diseases and vascular malformations of the nervous system; Veins & arteries; Japan; Radionuclide study; Human; Nervous system diseases; Exploration; Benzodiazepine receptor; Iomazenil(123I); Photon; Corpus callosum; Cerebral disorder; Central nervous system disease; Cerebrovascular disease; Brain (vertebrata); Emission tomography

OBJECTIVES It remains controversial whether selective neuronal ischaemic change develops in patients with occlusion of the large cerebral arteries. Previous studies have shown atrophy of the corpus callosum with reduced cortical oxygen metabolism in large cerebral arterial occlusive diseases, which...