Control of hyperuricemia in subjects with refractory gout, and induction of antibody against poly(ethylene glycol) (PEG), in a phase I trial of subcutaneous PEGylated urate oxidase - Ganson, Nancy J; Kelly, Susan J; Scarlett, Edna; Sundy, John S; Hershfield, Michael S (Arthritis research & therapy, 2006)
Keywords: Adult; Aged; Carbon Radioisotopes; Female; Gout - complications; Gout - drug therapy; Humans; Hyperuricemia - prevention & control; Immunoglobulin G - therapeutic use; Male; Middle Aged; Polyethylene Glycols - toxicity; Recombinant Proteins - toxicity; Urate Oxidase - immunology; Urate Oxidase - pharmacokinetics; Urate Oxidase - toxicity; Urea - analogs & derivatives; Urea - metabolism; Uric Acid - metabolism