NMDAR PAMs: Multiple Chemotypes for Multiple Binding Sites

• Published in: Current topics in medicinal chemistry Vol. 19; no. 24; p. 2239
• Main Author: Goldsmith, Paul J
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2019
• Subjects: Allosteric Regulation; Animals; Binding Sites; Excitatory Amino Acid Agents - therapeutic use; Humans; Mental Disorders - drug therapy; Receptors, N-Methyl-D-Aspartate - metabolism; Synaptic Transmission; Synaptic transmission; N-methyl-D-aspartate receptor; Schizophrenia; Positive allosteric modulator; Cognition; Glutamate receptor; Ion channel

The N-methyl-D-aspartate receptor (NMDAR) is a member of the ionotropic glutamate receptor (iGluR) family that plays a crucial role in brain signalling and development. NMDARs are nonselective cation channels that are involved with the propagation of excitatory neurotransmission signals with importa...