DNA Topoisomerases of Leishmania Parasites; Druggable Targets for Drug Discovery

• Published in: Current medicinal chemistry Vol. 26; no. 32; p. 5900
• Main Authors: Reguera, Rosa M, Elmahallawy, Ehab K, García-Estrada, Carlos, Carbajo-Andrés, Rubén, Balaña-Fouce, Rafael
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2019
• Subjects: Animals; Antiprotozoal Agents - chemistry; Antiprotozoal Agents - pharmacology; DNA Topoisomerases - metabolism; Drug Discovery; Humans; Leishmania - drug effects; Leishmania - enzymology; Parasitic Sensitivity Tests; Topoisomerase Inhibitors - chemistry; Topoisomerase Inhibitors - pharmacology; topoisomerases inhibitors; antileishmanial drugs; Topoisomerases; neglected tropical diseases; drug discovery; Leishmania

DNA topoisomerases (Top) are a group of isomerase enzymes responsible for controlling the topological problems caused by DNA double helix in the cell during the processes of replication, transcription and recombination. Interestingly, these enzymes have been known since long to be key molecular mach...