Therapeutic Targeting of the Soluble Guanylate Cyclase

• Published in: Current medicinal chemistry Vol. 26; no. 15; p. 2730
• Main Authors: Makrynitsa, Garyfallia I, Zompra, Aikaterini A, Argyriou, Aikaterini I, Spyroulias, Georgios A, Topouzis, Stavros
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2019
• Subjects: Cyclic guanosine monophosphate (cGMP); heme; sGC activators; H-NOX domain; sGC stimulators; Nitric oxide (NO); 6 Soluble guanylate cyclase (sGC); Fe

The soluble guanylate cyclase (sGC) is the physiological sensor for nitric oxide and alterations of its function are actively implicated in a wide variety of pathophysiological conditions. Intense research efforts over the past 20 years have provided significant information on its regulation, culmin...