Abnormally high expression of D1-like dopamine receptors on lupus CD4+ T cells promotes Tfh cell differentiation

• Published in: Lupus science & medicine Vol. 10; no. 2; p. e000943
• Main Authors: Wu, Fengxi, Xiang, Zhongyuan, He, Zhenghao, Yi, Ping, Yang, Ming, Wu, Haijing, Hu, Min
• Format: Journal Article
• Language: English
• Published: London Lupus Foundation of America 16.08.2023; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Antibodies; Autoimmune diseases; Catecholamines; Cytokines; Disease; Dopamine; Immune system; Immunology and Inflammation; Ions; Lupus; lupus erythematosus, systemic; Lymphocytes; Mass spectrometry; Proteins; Scientific imaging; T-lymphocytes, helper-inducer; China

ObjectiveSLE is a chronic autoimmune disease that places a great burden on human society. T follicular helper (Tfh) cells play a critical role in the pathological process of SLE. Therefore, elucidating the mechanism of Tfh cell differentiation will contribute to SLE treatment. Dopamine receptors (DR...