Xanthurenic acid translocates proapoptotic Bcl-2 family proteins into mitochondria and impairs mitochondrial function

• Published in: BMC cell biology Vol. 5; no. 1; p. 14
• Main Authors: Malina, Halina Z, Hess, Otto M
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 06.04.2004; BioMed Central; BMC
• Subjects: Apoptosis; Bad; Bak; Bax; bcl-2-Associated X Protein; bcl-X Protein; Bcl-xs; Ca2; Calcium - metabolism; Cells, Cultured; human aortic smooth muscle cells; Humans; mitochondria; Mitochondria - metabolism; Mitochondria - physiology; Mitochondria, Liver - drug effects; Mitochondria, Liver - metabolism; Muscle, Smooth, Vascular - cytology; Muscle, Smooth, Vascular - drug effects; Muscle, Smooth, Vascular - metabolism; O2 consumption; Oxygen Consumption; Protein Transport; Proto-Oncogene Proteins - metabolism; Proto-Oncogene Proteins c-bcl-2 - metabolism; translocation; Xanthurenates - pharmacology; xanthurenic acid

Xanthurenic acid is an endogenous molecule produced by tryptophan degradation, produced in the cytoplasm and mitochondria. Its accumulation can be observed in aging-related diseases, e.g. senile cataract and infectious disease. We previously reported that xanthurenic acid provokes apoptosis, and now...