The Importance of Linkers in the Structure of PSMA Ligands

• Published in: Current medicinal chemistry Vol. 29; no. 2; p. 268
• Main Authors: Uspenskaya, Anastasia A, Nimenko, Ekaterina A, Machulkin, Aleksei E, Beloglazkina, Elena K, Majouga, Alexander G
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 2022
• Subjects: Cell Line, Tumor; Drug Delivery Systems; Humans; Ligands; Male; Peptides - therapeutic use; Prostatic Neoplasms - drug therapy; Structure-Activity Relationship; linker; target drug delivery; PSMA; linker’s structure; spacer; Prostate cancer; synthesis of conjugates

Cancer is one of the leading social problems of the modern world. Today prostate cancer is the second leading cause of cancer deaths among men. Targeted drug delivery is widely used to treat and diagnose prostate cancer. Conjugates selectively binding to prostatespecific membrane antigen-based on ur...