Aesculetin Inhibits Proliferation and Induces Mitochondrial Apoptosis in Bladder Cancer Cells by Suppressing the MEK/ERK Signaling Pathway

• Published in: Anti-cancer agents in medicinal chemistry Vol. 23; no. 4; p. 478
• Main Authors: Han, Li, Li, Peiwu, Fu, Xu, Huang, Zhenzhen, Yin, Wen
• Format: Journal Article
• Language: English
• Published: Netherlands 01.01.2023
• Subjects: Apoptosis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Humans; MAP Kinase Signaling System; Mitochondria; Mitogen-Activated Protein Kinase Kinases - metabolism; Signal Transduction; Urinary Bladder Neoplasms - metabolism; migration and invasion; apoptosis; aesculetin; proliferation; Bladder cancer; MEK/ERK

Aesculetin (AE), a natural coumarin derivative found in traditional medicinal herbs, has a variety of pharmacological effects. However, the role of AE and its molecular mechanisms of action on bladder cancer remains undefined. The study aims to explore the anti-tumor effects of AE on bladder cancer...