TNF-α and IL-6: The Link between Immune and Bone System

• Published in: Current drug targets Vol. 21; no. 3; p. 213
• Main Authors: Wang, Tiantian, He, Chengqi
• Format: Journal Article
• Language: English
• Published: United Arab Emirates 01.01.2020
• Subjects: Animals; Arthritis, Rheumatoid - immunology; Arthritis, Rheumatoid - metabolism; Bone and Bones - immunology; Bone and Bones - metabolism; Humans; Interleukin-6 - metabolism; Osteoblasts - immunology; Osteoblasts - metabolism; Osteoclasts - immunology; Osteoclasts - metabolism; Osteoporosis, Postmenopausal - immunology; Osteoporosis, Postmenopausal - metabolism; Tumor Necrosis Factor-alpha - metabolism; osteoblast; osteocyte; TNF-α; osteoclast; IL-6; osteoimmunology

Osteoimmunology is a new subject which focuses on the communication between the immune and the skeletal systems. Both the immune system and bone communicate with each other. Proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) play important roles in immune...