Alantolactone Inhibits Melanoma Cell Culture Viability and Migration and Promotes Apoptosis by Inhibiting Wnt/β-Catenin Signaling

• Published in: Anti-cancer agents in medicinal chemistry Vol. 23; no. 1; p. 94
• Main Authors: Zhang, Lingzhao, Chen, Jiayi, Chen, Yangmei, Zou, Daopei, Pu, Yihuan, Wei, Mengqi, Huang, Yanran, Li, Yuxin, Huang, Qing, Chen, Jin
• Format: Journal Article
• Language: English
• Published: Netherlands 2023
• Subjects: Animals; Apoptosis; bcl-2-Associated X Protein; beta Catenin - metabolism; Cadherins; Caspase 3 - metabolism; Cell Culture Techniques; Cell Line, Tumor; Cell Movement; Glycogen Synthase Kinase 3 beta - metabolism; Glycogen Synthase Kinase 3 beta - pharmacology; Humans; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 7 - metabolism; Matrix Metalloproteinase 9 - metabolism; Melanoma, Cutaneous Malignant; Melanoma, Experimental - pathology; Mice; Mice, Nude; Proliferating Cell Nuclear Antigen - metabolism; Proliferating Cell Nuclear Antigen - pharmacology; Vimentin - metabolism; Wnt Signaling Pathway; anti-tumor; Chinese medicinal herb; cell culture; Wnt/β-catenin; Melanoma; apoptosis; alantolactone

Melanoma is a highly invasive and metastatic malignant tumor originating from melanocytes and is associated with a poor prognosis. Surgical resection and chemotherapy are currently the main therapeutic options for malignant melanoma; however, their efficacy is poor, highlighting the need for the dev...