COX-2 inhibition with rofecoxib does not increase intestinal permeability in healthy subjects: a double blind crossover study comparing rofecoxib with placebo and indomethacin

• Published in: Gut Vol. 47; no. 4; pp. 527 - 532
• Main Authors: Sigthorsson, G, Crane, R, Simon, T, Hoover, M, Quan, H, Bolognese, J, Bjarnason, I
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.10.2000; BMJ; BMJ Publishing Group LTD
• Subjects: Adolescent; Adult; Arthritis; Biological and medical sciences; Bones, joints and connective tissue. Antiinflammatory agents; Chromium Radioisotopes - metabolism; COX-2 inhibitor; Cross-Over Studies; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors - pharmacology; Disease; Double-Blind Method; Drug dosages; Edetic Acid - metabolism; Family medical history; Female; Gastroesophageal reflux; Humans; indomethacin; Indomethacin - pharmacology; Inflammation; Intestinal Mucosa - drug effects; Intestinal Mucosa - metabolism; intestinal permeability; Isoenzymes - metabolism; Laboratories; Lactones - pharmacology; Male; Medical sciences; Membrane Proteins; Metabolism; Metabolites; non-steroidal anti-inflammatory drugs; Older people; osteoarthritis; Permeability; Pharmacology. Drug treatments; Prostaglandin-Endoperoxide Synthases - metabolism; rofecoxib; Small intestine; Studies; Sulfones; Human; Prostaglandin-endoperoxide synthase; Cell permeability; Enzyme; Treatment efficiency; Antiinflammatory agent; Indometacin; Gut; Cell biology; Enzyme inhibitor; Asymptomatic; Tocolytic; Non steroidal antiinflammatory agent; Placebo; Indoleacetic acid derivatives; Secondary effect; Double blind study; Oxidoreductases; Comparative study

BACKGROUND Acute and chronic use of non-steroidal anti-inflammatory drugs can increase intestinal permeability. Rofecoxib, which selectively inhibits cyclooxygenase 2 (COX-2), is a novel anti-inflammatory drug with the potential to produce minimal gastrointestinal toxic effects while retaining clini...