Faecal microbiota transplantation halts progression of human new-onset type 1 diabetes in a randomised controlled trial

• Published in: Gut Vol. 70; no. 1; pp. 92 - 105
• Main Authors: de Groot, Pieter, Nikolic, Tanja, Pellegrini, Silvia, Sordi, Valeria, Imangaliyev, Sultan, Rampanelli, Elena, Hanssen, Nordin, Attaye, Ilias, Bakker, Guido, Duinkerken, Gaby, Joosten, Antoinette, Prodan, Andrei, Levin, Evgeni, Levels, Han, Potter van Loon, Bartjan, van Bon, Arianne, Brouwer, Catherina, van Dam, Sytze, Simsek, Suat, van Raalte, Daniel, Stam, Frank, Gerdes, Victor, Hoogma, Roel, Diekman, Martin, Gerding, Martin, Rustemeijer, Cees, de Bakker, Bernadette, Hoekstra, Joost, Zwinderman, Aeilko, Bergman, Jacques, Holleman, Frits, Piemonti, Lorenzo, De Vos, Willem, Roep, Bart, Nieuwdorp, Max
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.01.2021; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Adolescent; Adult; Autografts; Autoimmune diseases; Autoimmunity; Beta cells; C-Peptide - metabolism; CCL22 protein; CD4 antigen; CXCR3 protein; Diabetes; diabetes mellitus; Diabetes mellitus (insulin dependent); Diabetes Mellitus, Type 1 - metabolism; Diabetes Mellitus, Type 1 - microbiology; Diabetes Mellitus, Type 1 - prevention & control; Digestive system; Duodenum - metabolism; Duodenum - microbiology; Fecal Microbiota Transplantation - methods; Female; Gastrointestinal Microbiome; Gastrointestinal tract; Gene expression; Gut Microbiota; Humans; Immune system; Immunology; Insulin; Insulin resistance; Insulin-Secreting Cells - physiology; Intestinal microflora; Intestine; Lymphocytes; Lymphocytes T; Male; Metabolism; Metabolites; Microbiomes; Microbiota; Pathophysiology; Peptides; Plasma; Preservation; Quantum dots; Transplantation; Transplantation, Autologous; Young Adult; diabetes mellitus

ObjectiveType 1 diabetes (T1D) is characterised by islet autoimmunity and beta cell destruction. A gut microbiota–immunological interplay is involved in the pathophysiology of T1D. We studied microbiota-mediated effects on disease progression in patients with type 1 diabetes using faecal microbiota...