Impairment of spermatogenesis and sperm motility by the high-fat diet-induced dysbiosis of gut microbes

• Published in: Gut Vol. 69; no. 9; pp. 1608 - 1619
• Main Authors: Ding, Ning, Zhang, Xin, Zhang, Xue Di, Jing, Jun, Liu, Shan Shan, Mu, Yun Ping, Peng, Li Li, Yan, Yun Jing, Xiao, Geng Miao, Bi, Xin Yun, Chen, Hao, Li, Fang Hong, Yao, Bing, Zhao, Allan Z
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.09.2020; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Animals; Antibodies; Bacteroides; Bacteroides - isolation & purification; Chronic illnesses; Correlation of Data; Cytokines; Cytokines - analysis; Deoxyribonucleic acid; Diabetes; Diet; Diet, High-Fat - adverse effects; Digestive system; DNA; Dysbacteriosis; Dysbiosis - etiology; Dysbiosis - microbiology; Endotoxemia - microbiology; endotoxin; Epididymis; Epididymis - immunology; Epididymis - pathology; Feces - microbiology; Gastric motility; Gastrointestinal Microbiome - immunology; Gastrointestinal tract; Gene expression; Glucose; Gut Microbiota; High fat diet; Humans; Infertility; Inflammation; intestinal microbiology; Intestinal microflora; Intestine; Lymphocytes T; Macrophages; Macrophages - immunology; Male; Meiosis; Metabolic disorders; Mice; Microbiota; Microorganisms; Mitochondria; Motility; Obesity; Prevotella; Prevotella - isolation & purification; Ribonucleic acid; RNA; Sperm; Sperm Motility - immunology; Spermatogenesis; Spermatogenesis - immunology; T-Lymphocytes - immunology; Testes; Transplantation; China; intestinal microbiology; diet; inflammation; endotoxin

ObjectiveHigh-fat diet (HFD)-induced metabolic disorders can lead to impaired sperm production. We aim to investigate if HFD-induced gut microbiota dysbiosis can functionally influence spermatogenesis and sperm motility.DesignFaecal microbes derived from the HFD-fed or normal diet (ND)-fed male mice...