Genome-wide mapping of 5-hydroxymethylcytosines in circulating cell-free DNA as a non-invasive approach for early detection of hepatocellular carcinoma

• Published in: Gut Vol. 68; no. 12; pp. 2195 - 2205
• Main Authors: Cai, Jiabin, Chen, Lei, Zhang, Zhou, Zhang, Xinyu, Lu, Xingyu, Liu, Weiwei, Shi, Guoming, Ge, Yang, Gao, Pingting, Yang, Yuan, Ke, Aiwu, Xiao, Linlin, Dong, Ruizhao, Zhu, Yanjing, Yang, Xuan, Wang, Jiefei, Zhu, Tongyu, Yang, Deping, Huang, Xiaowu, Sui, Chengjun, Qiu, Shuangjian, Shen, Feng, Sun, Huichuan, Zhou, Weiping, Zhou, Jian, Nie, Ji, Zeng, Chang, Stroup, Emily Kunce, Zhang, Xu, Chiu, Brian C-H, Lau, Wan Yee, He, Chuan, Wang, Hongyang, Zhang, Wei, Fan, Jia
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.12.2019; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original article
• Subjects: 5-Methylcytosine - analogs & derivatives; 5-Methylcytosine - blood; Biomarkers; Biomarkers, Tumor - blood; Biopsy; cancer; Carcinoma, Hepatocellular - blood; Carcinoma, Hepatocellular - diagnosis; Carcinoma, Hepatocellular - genetics; Cell-Free Nucleic Acids - blood; Chronic infection; Cirrhosis; Clinical outcomes; Deoxyribonucleic acid; DNA; DNA, Neoplasm - analysis; Early Detection of Cancer - methods; Epigenetics; Female; Gastroenterology; Gene expression; Gene mapping; Generalized linear models; Genome-Wide Association Study - methods; Genomes; Health care; Hepatitis; Hepatitis B; hepatobiliary cancer; Hepatocellular carcinoma; Hepatology; Hospitals; Humans; Liver cancer; Liver cirrhosis; Liver Neoplasms - blood; Liver Neoplasms - diagnosis; Liver Neoplasms - genetics; Male; Medical prognosis; Middle Aged; Patients; Prospective Studies; ROC Curve; Signal transduction; Surveillance; Tumors; α-Fetoprotein; Chicago Illinois; United States > US; Illinois; China; hepatobiliary cancer; cancer; hepatocellular carcinoma

ObjectiveThe lack of highly sensitive and specific diagnostic biomarkers is a major contributor to the poor outcomes of patients with hepatocellular carcinoma (HCC). We sought to develop a non-invasive diagnostic approach using circulating cell-free DNA (cfDNA) for the early detection of HCC.DesignA...