Effects of amniotic membrane on epithelial wound healing and stromal remodelling after excimer laser keratectomy in rabbit cornea

• Published in: British journal of ophthalmology Vol. 85; no. 3; pp. 345 - 349
• Main Authors: Woo, H-M, Kim, M S, Kweon, O-K, Kim, D-Y, Nam, T-C, Kim, J H
• Format: Journal Article
• Language: English
• Published: BMA House, Tavistock Square, London, WC1H 9JR BMJ Publishing Group Ltd 01.03.2001; BMJ; BMJ Publishing Group LTD
• Subjects: amniotic membrane; Animals; Apoptosis; Biological and medical sciences; Biological Dressings; Cell Count; Collagen; Corneal Stroma - physiology; Epidermal growth factor; epithelial healing; Epithelium, Corneal - physiology; excimer laser keratectomy; Fluoresceins; Fluorescent Dyes; Image Processing, Computer-Assisted; Lasers; Lasers, Excimer; Medical sciences; Original articles - Laboratory science; Photorefractive Keratectomy - methods; Rabbits; Rodents; Staining and Labeling; stromal remodelling; Surgery; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the eye and orbit; Time Factors; Wound healing; Wound Healing - physiology; Surgical wound; Postoperative; Prognosis; Rabbit; Keratectomy; Lagomorpha; Epithelium; Experimental study; Photocoagulation; Dressing; Vertebrata; Mammalia; Surgery; Animal; Excimer; Laser; Amnion; Membrane; Cicatrization

AIMS To investigate if the amniotic membrane (AM) promotes epithelial migration while inhibiting stromal remodelling associated with corneal haze after excimer laser keratectomy. METHODS A wound 150 μm in depth and 6.0 mm in diameter was produced in 40 rabbits using an excimer laser. One eye was ran...