Divergent patterns of matrix metalloproteinase activity during wound healing in ileum and colon of rats

• Published in: Gut Vol. 39; no. 1; pp. 114 - 119
• Main Authors: Seifert, W F, Wobbes, T, Hendriks, T
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.07.1996; BMJ; BMJ Publishing Group LTD
• Subjects: Animals; Biological and medical sciences; Colon - enzymology; Colon - surgery; Electrophoresis; Gelatinases - analysis; Ileum - enzymology; Ileum - surgery; Male; Medical sciences; Metalloendopeptidases - analysis; Postoperative Period; Random Allocation; Rats; Stomach, duodenum, intestine, rectum, anus; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the digestive system; Wound Healing; Rat; Enzyme; Cure; Rodentia; Surgical anastomosis; Experimental study; Ileum; Metalloproteins; Vertebrata; Mammalia; Microbiological investigation; Surgery; Animal; Digestive diseases; Hydrolases; Intestinal disease; Colon; Biological effect; Proteinases

BACKGROUND: Uncontrolled and increased extracellular matrix degradation during early anastomotic repair in the intestine may reduce wound strength increasing the risk of anastomotic dehiscence. AIMS: To characterise the metalloproteinases present in intact and anastomosed ileum and colon to study th...