Langerhans' cells are depleted in chronic graft versus host disease

• Published in: Journal of clinical pathology Vol. 50; no. 4; pp. 305 - 309
• Main Authors: Aractingi, S, Gluckman, E, Dauge-Geffroy, M C, Le Goué, C, Flahaut, A, Dubertret, L, Carosella, E
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and Association of Clinical Pathologists 01.04.1997; BMJ; BMJ Publishing Group LTD
• Subjects: Adolescent; Adult; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Biological and medical sciences; Bone Marrow Transplantation; Bone marrow, stem cells transplantation. Graft versus host reaction; Female; Graft vs Host Disease - complications; Graft vs Host Disease - pathology; Humans; Langerhans Cells - cytology; Langerhans Cells - immunology; Male; Medical sciences; Middle Aged; Skin Diseases - pathology; Transfusions. Complications. Transfusion reactions. Cell and gene therapy; Human; Immunohistochemistry; Immunopathology; Skin disease; Circumscribed scleroderma; Graft versus host reaction; Transplantation; Homotransplantation; Lichen planus; Pathology; Langerhans cell; Surgery; Bone marrow; Morphometry; Quantitative analysis

AIMS: To measure Langerhans' cells in skin of patients treated by bone marrow transplantation who developed chronic graft versus host disease (GvHD); to determine whether the reduction in Langerhans' cells resulted directly from the GvHD or from other factors, such as the immunosuppressive...