Vinblastine resets tumor-associated macrophages toward M1 phenotype and promotes antitumor immune response

• Published in: Journal for immunotherapy of cancer Vol. 11; no. 8; p. e007253
• Main Authors: Wang, Yi-Na, Wang, Yuan-Yuan, Wang, Jin, Bai, Wen-Juan, Miao, Nai-Jun, Wang, Jing
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.08.2023; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Biosynthesis; Bone marrow; Cancer; CD8-positive T-lymphocytes; Cell growth; Chemotherapy; combined modality therapy; Cytotoxicity; drug therapy, combination; Drugs; Flow cytometry; Genotype & phenotype; Immune Cell Therapies and Immune Cell Engineering; Immune response; immunohistochemistry; Immunotherapy; Lymphocytes; macrophages; Metastasis; Morphology; Reactive oxygen species; Tumors

BackgroundMassive tumor-associated macrophage (TAM) infiltration is observed in many tumors, which usually display the immune-suppressive M2-like phenotype but can also be converted to an M1-like antitumor phenotype due to their high degree of plasticity. The macrophage polarization state is associa...