Inhibition of Tumor Cell Invasiveness by Chemically Modified Tetracyclines

• Published in: Current medicinal chemistry Vol. 8; no. 3; pp. 261 - 270
• Main Authors: GU, Y, LEE, H. M, ROEMER, E. J, MUSACCHIA, L, GOLUB, L. M, SIMON, S. R
• Format: Journal Article
• Language: English
• Published: Schiphol Bentham Science Publishers Ltd 01.02.2001; Bentham Science
• Subjects: Antineoplastic agents; Antineoplastic Agents - toxicity; Biological and medical sciences; Cell Survival - drug effects; Colonic Neoplasms - pathology; Culture Media, Conditioned; Culture Media, Serum-Free; Cytotoxicity; Doxycycline - toxicity; Extracellular Matrix - metabolism; General aspects; Humans; Male; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases - metabolism; Medical sciences; Neoplasm Invasiveness - prevention & control; Pharmacology. Drug treatments; Prostate - drug effects; Prostatic Neoplasms - pathology; Stromal Cells - drug effects; tetracyclines; Tetracyclines - toxicity; Tumor Cells, Cultured; Tumors; Antineoplastic agent; Metalloendopeptidases; Cytotoxicity; Selectivity; Degradation; Extracellular matrix; Colon; Inhibition; Mechanism of action; Tumor cell; Human; Enzyme; Tetracycline derivatives; Enzyme inhibitor; Antimetastatic agent; Epithelium; Gene expression; In vitro; Biological activity; Gelatinase B; Gelatinase A; Peptidases; Chemical modification; Cell line; Hydrolases; Prostate

COLO 205 is a cell line derived from a human colon carcinoma with high degradative activity towards extracellular matrix (ECM). It has been shown that COLO 205 cells produce matrix metalloproteinases (MMPs). MMPs are a family of enzymes known to degrade components of the ECM and have been implicated...