Snail-regulated exosomal microRNA-21 suppresses NLRP3 inflammasome activity to enhance cisplatin resistance

• Published in: Journal for immunotherapy of cancer Vol. 10; no. 8; p. e004832
• Main Authors: Cheng, Han-Ying, Hsieh, Chia-Hsin, Lin, Po-Han, Chen, Yu-Tung, Hsu, Dennis Shin-Shian, Tai, Shyh-Kuan, Chu, Pen-Yuan, Yang, Muh-Hwa
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd 01.08.2022; BMJ Publishing Group LTD; BMJ Publishing Group
• Series: Original research
• Subjects: Adaptation; Adapter proteins; Basic Tumor Immunology; Breast cancer; Cancer; Cancer therapies; Chemotherapy; Cytokines; Evolution & development; Experiments; Gene expression; Genomics; Head & neck cancer; head and neck neoplasms; immunity, innate; Immunotherapy; Inflammation; Lung cancer; macrophages; MicroRNAs; Oral cancer; Plasmids; Software; tumor microenvironment; Tumor necrosis factor-TNF; Tumors; Taiwan

BackgroundCompared with the precise targeting of drug-resistant mutant cancer cells, strategies for eliminating non-genetic adaptation-mediated resistance are limited. The pros and cons of the existence of inflammasomes in cancer have been reported. Nevertheless, the dynamic response of inflammasome...