XRN1 is a Species-Specific Virus Restriction Factor in Yeasts

• Published in: bioRxiv
• Main Authors: Rowley, Paul A, Ho, Brandon, Bushong, Sarah, Johnson, Arlen, Sawyer, Sara L
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 16.08.2016; Cold Spring Harbor Laboratory
• Edition: 1.1
• Subjects: Adaptive immunity; Amino acid sequence; Antiviral activity; Biodegradation; Enzymatic activity; Evolutionary Biology; Exonuclease; Gag protein; Natural selection; Ribonucleic acid; RNA; Species; Viruses; Yeast

In eukaryotes, the degradation of cellular mRNAs is accomplished by Xrn1p and the cytoplasmic exosome. Because viral RNAs often lack canonical caps or poly-A tails, they can also be vulnerable to degradation by these host exonucleases. Yeast lack sophisticated mechanisms of innate and adaptive immun...