Effects of exercise on mitochondrial DNA content in skeletal muscle of patients with COPD

• Published in: Thorax Vol. 66; no. 2; pp. 121 - 127
• Main Authors: Puente-Maestu, Luis, Lázaro, Alberto, Tejedor, Alberto, Camaño, Sonia, Fuentes, Marta, Cuervo, Miguel, Navarro, Beatriz Oláiz, Agustí, Alvar
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Thoracic Society 01.02.2011; BMJ Publishing Group; BMJ Publishing Group LTD
• Subjects: Aged; Biological and medical sciences; Biopsy; Body mass index; Cardiology. Vascular system; Case-Control Studies; Chronic obstructive pulmonary disease; Chronic obstructive pulmonary disease, asthma; coactivator-1α; COPD mechanisms; DNA damage; DNA, Mitochondrial - metabolism; Exercise; Exercise - physiology; Humans; Investigations; Lactic Acid - biosynthesis; Medical sciences; Middle Aged; mitochondria biogenesis; Mitochondria, Muscle - metabolism; Mitochondrial DNA; Muscle, Skeletal - metabolism; Musculoskeletal system; Oxidation; oxidative stress; Oxidative Stress - genetics; Oxygen Consumption - physiology; peroxisome proliferator-activated receptor-γ; Pneumology; Polymerase Chain Reaction - methods; Prospective Studies; Pulmonary Disease, Chronic Obstructive - genetics; Pulmonary Disease, Chronic Obstructive - metabolism; pulmonary rehabilitation; quadriceps muscle injury; Reactive Oxygen Species - metabolism; Spirometry; Spirometry - methods; superoxide dismutase; Ventilation; United States > US; Germany; California; Physical exercise; Human; Lung disease; Respiratory disease; Patient; Mitochondrial DNA; Striated muscle; Chronic; Bronchus disease; Anesthesia; Exercise tolerance test; Chronic obstructive pulmonary disease; Circulatory system; Obstructive pulmonary disease; Cardiology

BackgroundExhausting exercise reduces the mitochondrial DNA (mtDNA) content in the skeletal muscle of healthy subjects due to oxidative damage. Since patients with chronic obstructive pulmonary disease (COPD) suffer enhanced oxidative stress during exercise, it was hypothesised that the mtDNA conten...