COGNITIVE ENDOPHENOTYPES OF MODERN AND EXTINCT HOMININS ASSOCIATED WITH NTNG GENE PARALOGS

• Published in: bioRxiv
• Main Authors: Prosselkov, Pavel, Hashimoto, Ryota, Polygalov, Denis, Ohi Kazutaka, Zhang, Qi, Mchugh, Thomas J, Takeda, Masatoshi, Itohara, Shigeyoshi
• Format: Paper
• Language: English
• Published: Cold Spring Harbor Cold Spring Harbor Laboratory Press 04.04.2016; Cold Spring Harbor Laboratory
• Edition: 1.8
• Subjects: Alleles; Amino acid sequence; Cognitive ability; Conserved sequence; Embedding; Genomes; Genomics; Information processing; Intelligence; Intelligence tests; Mental disorders; Mutation; Schizophrenia; Short term memory; Single-nucleotide polymorphism; psychogenetics; paleogenetics; evolution; cognitive endophenotype; gene duplication

A pair of vertebrate-specific and brain-expressed pre-synaptic genes, NTNG1 and NTNG2, contributes to the Intellectual Quotient (IQ) test scores in a complementary manner. Single nucleotide polymorphisms (SNPs) of NTNG1 are associated with attenuated verbal comprehension (VC) or processing speed (PS...