Dysbiosis of the faecal microbiota in patients with Crohn's disease and their unaffected relatives

• Published in: Gut Vol. 60; no. 5; pp. 631 - 637
• Main Authors: Joossens, Marie, Huys, Geert, Cnockaert, Margo, De Preter, Vicky, Verbeke, Kristin, Rutgeerts, Paul, Vandamme, Peter, Vermeire, Severine
• Format: Journal Article
• Language: English
• Published: London BMJ Publishing Group Ltd and British Society of Gastroenterology 01.05.2011; BMJ Publishing Group; BMJ Publishing Group LTD
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Autophagy; Bacteria; Bacteria - classification; Bacteria - isolation & purification; Bifidobacterium adolescentis; Biological and medical sciences; Biopsy; Case-Control Studies; Clostridium; Collinsella aerofaciens; Crohn Disease - genetics; Crohn Disease - microbiology; Crohn's disease; Denaturing Gradient Gel Electrophoresis - methods; DGGE; DNA, Bacterial - analysis; dysbiosis; Escherichia; Faecalibacterium prausnitzii; Feces - microbiology; Female; Gastroenterology. Liver. Pancreas. Abdomen; Genotype & phenotype; Humans; Inflammatory bowel disease; Irritable bowel syndrome; Male; Medical sciences; Metagenome; Middle Aged; mucin degradation; Other diseases. Semiology; Reverse Transcriptase Polymerase Chain Reaction - methods; Ruminococcus; Ruminococcus gnavus; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Studies; Symbiosis - genetics; Young Adult; Human; Crohn disease; Gastroenterology; Digestive diseases; Intestinal disease; Feces; Inflammatory disease

Background and aimsA general dysbiosis of the intestinal microbiota has been established in patients with Crohn's disease (CD), but a systematic characterisation of this dysbiosis is lacking. Therefore the composition of the predominant faecal microbiota of patients with CD was studied in compa...