4-Aryl-4H-chromene-3-carbonitrile derivatives: evaluation of Src kinase inhibitory and anticancer activities

• Published in: Medicinal chemistry (Shp-sariqah, United Arab Emirates) Vol. 7; no. 5; p. 466
• Main Authors: Fallah-Tafti, Asal, Tiwari, Rakesh, Shirazi, Amir Nasrolahi, Akbarzadeh, Tahmineh, Mandal, Deendayal, Shafiee, Abbas, Parang, Keykavous, Foroumadi, Alireza
• Format: Journal Article
• Language: English
• Published: Netherlands 01.09.2011
• Subjects: Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Benzopyrans - chemical synthesis; Benzopyrans - chemistry; Benzopyrans - pharmacology; Cell Proliferation - drug effects; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Models, Molecular; Protein Kinase Inhibitors - chemical synthesis; Protein Kinase Inhibitors - chemistry; Protein Kinase Inhibitors - pharmacology; src-Family Kinases - antagonists & inhibitors; src-Family Kinases - metabolism; Structure-Activity Relationship; Tumor Cells, Cultured
• ISSN: 1875-6638
• DOI: 10.2174/157340611796799258

Src kinase mutations and/or overexpression have been implicated in the development of a number of human cancer including colon, breast, and lung cancers. Thus, designing potent and selective Src kinase inhibitors as anticancer agents is a subject of major interest. A series of 4-aryl substituted der...