New insights on flavonoid-serum albumin interactions from concerted spectroscopic methods and molecular modeling

• Published in: Current drug metabolism Vol. 14; no. 4; p. 474
• Main Authors: Ionescu, Sorana, Matei, Iulia, Tablet, Cristina, Hillebrand, Mihaela
• Format: Journal Article
• Language: English
• Published: Netherlands 01.05.2013
• Subjects: Animals; Binding Sites; Flavonoids - chemistry; Flavonoids - metabolism; Humans; Models, Molecular; Protein Binding; Protein Conformation; Serum Albumin - chemistry; Serum Albumin - metabolism; Spectrum Analysis - methods

The paper offers a survey on literature data on the very wide subject concerning the interaction of a particular class of polyphenols, flavonoids, with plasma proteins. Recent developments in applying fluorescence (steady-state, time-resolved, synchronous techniques), circular dichroism and vibratio...