Mutant GNAS detected in duodenal collections of secretin-stimulated pancreatic juice indicates the presence or emergence of pancreatic cysts

• Published in: Gut Vol. 62; no. 7; pp. 1024 - 1033
• Main Authors: Kanda, Mitsuro, Knight, Spencer, Topazian, Mark, Syngal, Sapna, Farrell, James, Lee, Jeffrey, Kamel, Ihab, Lennon, Anne Marie, Borges, Michael, Young, Angela, Fujiwara, Sho, Seike, Junro, Eshleman, James, Hruban, Ralph H, Canto, Marcia Irene, Goggins, Michael
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd and British Society of Gastroenterology 01.07.2013; BMJ Publishing Group LTD
• Subjects: Aged; Aged, 80 and over; Biomarkers, Tumor - genetics; Carcinoma, Pancreatic Ductal - diagnosis; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - pathology; Case-Control Studies; Chromogranins; colonic polyps; Cysts; Deoxyribonucleic acid; DNA; DNA, Neoplasm - genetics; Duodenum - metabolism; Early Detection of Cancer - methods; Early Diagnosis; endoscopic retrograde pancreatography; endoscopic ultrasonography; Endoscopy; Family medical history; Female; gastrointesinal endoscopy; gastrointestinal neoplasia; gastrointestinal ultrasound; Genetic Predisposition to Disease; GNAS; GTP-Binding Protein alpha Subunits, Gs - genetics; GTP-Binding Protein alpha Subunits, Gs - secretion; Hogs; Humans; intraductal papillary mucinous neoplasm; Male; methylation; Middle Aged; Mutation; Neoplasm Proteins - genetics; Neoplasm Proteins - secretion; oncogenes; pancreas; Pancreatic cancer; pancreatic cyst; Pancreatic Cyst - diagnosis; Pancreatic Cyst - genetics; Pancreatic Cyst - pathology; pancreatic disease; pancreatic disorders; pancreatic juice; Pancreatic Juice - metabolism; Pancreatic Neoplasms - diagnosis; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - pathology; pancreatic tumours; Rodents; Secretin; Studies; Surveillance; Tumors; Ultrasonic imaging; gastrointestinal ultrasound; pancreatic juice; oncogenes; endoscopy; intraductal papillary mucinous neoplasm; pancreatic cyst; colonic polyps; endoscopic retrograde pancreatography; pancreatic disorders; endoscopic ultrasonography; Pancreatic cancer; methylation; pancreas; GNAS; gastrointesinal endoscopy; pancreatic disease; gastrointestinal neoplasia; pancreatic tumours

Objective Pancreatic cysts are commonly detected in patients undergoing pancreatic imaging. Better approaches are needed to characterise these lesions. In this study we evaluated the utility of detecting mutant DNA in secretin-stimulated pancreatic juice. Design Secretin-stimulated pancreatic juice...