Aurora A Kinase (AURKA) is required for male germline maintenance and regulates sperm motility in the mouse

• Published in: Biology of reproduction Vol. 105; no. 6; pp. 1603 - 1616
• Main Authors: Lester, William C, Johnson, Taylor, Hale, Ben, Serra, Nicholas, Elgart, Brian, Wang, Rong, Geyer, Christopher B, Sperry, Ann O
• Format: Journal Article
• Language: English
• Published: United States Society for the Study of Reproduction 20.12.2021; Oxford University Press
• Subjects: Animals; Aurora A kinase (AURKA); Aurora Kinase A - deficiency; Aurora Kinase A - genetics; Aurora Kinase A - metabolism; Genetically modified animals; Male; Mice - genetics; Mice - physiology; Mice, Knockout; Phosphatases; Protein phosphatase 1 (PP1); RESEARCH ARTICLE; sperm motility; Sperm Motility - genetics; spermatogenesis; Spermatogenesis - genetics; Spermatozoa; Spermatozoa - enzymology; spermiogenesis; Testis - growth & development; spermatogenesis; sperm motility; Protein phosphatase 1 (PP1); spermiogenesis; Aurora A kinase (AURKA)

Aurora A kinase (AURKA) is an important regulator of cell division and is required for assembly of the mitotic spindle. We recently reported the unusual finding that this mitotic kinase is also found on the sperm flagellum. To determine its requirement in spermatogenesis, we generated conditional kn...