Descemet Endothelial Thickness Comparison Trial II (DETECT II): multicentre, outcome assessor-masked, placebo-controlled trial comparing Descemet membrane endothelial keratoplasty (DMEK) to Descemet stripping only (DSO) with adjunctive ripasudil for Fuchs dystrophy

• Published in: BMJ open ophthalmology Vol. 9; no. 1; p. e001725
• Main Authors: Lin, Charles C, Chamberlain, Winston, Benetz, Beth Ann, Gensheimer, William, Li, Jennifer Y, Jeng, Bennie H, Clover, Jameson, Varnado, Nicole, Abdelrahman, Sarah, Srinivasan, Amrita, Syed, Zeba A, Koo, Ellen H, Arnold, Benjamin F, Lietman, Thomas M, Lass, Jonathan, Rose-Nussbaumer, Jennifer
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd 01.10.2024; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Adjuvants; Aged; Cataracts; Cell cycle; clinical trial; Clinical trials; Committees; cornea; Corneal transplantation; Descemet Membrane - surgery; Descemet Stripping Endothelial Keratoplasty - methods; Endothelium; Endothelium, Corneal - pathology; Eye surgery; Female; Fuchs' Endothelial Dystrophy - drug therapy; Fuchs' Endothelial Dystrophy - surgery; Humans; Intraocular lenses; Isoquinolines - administration & dosage; Isoquinolines - therapeutic use; Kinases; Male; Middle Aged; Multicenter Studies as Topic; Ophthalmic Solutions - therapeutic use; Patients; Protocol; Sulfonamides - administration & dosage; Sulfonamides - therapeutic use; Surgeons; Treatment Outcome; Visual acuity; Visual Acuity - drug effects; Oregon; Sacramento California; San Francisco California; California; United States > US; Pennsylvania; clinical trial; cornea

IntroductionIt remains uncertain whether Descemet membrane endothelial keratoplasty (DMEK) or Descemet stripping only (DSO) yields better outcomes in patients with symptomatic Fuchs endothelial corneal dystrophy (FECD). This paper presents the protocol for the Descemet Endothelial Thickness Comparis...