Magnetic brain stimulation using iron oxide nanoparticle-mediated selective treatment of the left prelimbic cortex as a novel strategy to rapidly improve depressive-like symptoms in mice

• Published in: Dōngwùxué yánjiū Vol. 41; no. 4; pp. 381 - 394
• Main Authors: Lu, Qing-Bo, Sun, Jian-Fei, Yang, Qu-Yang, Cai, Wen-Wen, Xia, Meng-Qin, Wu, Fang-Fang, Gu, Ning, Zhang, Zhi-Jun
• Format: Journal Article
• Language: English
• Published: China Kunming Institute of Zoology, The Chinese Academy of Sciences 18.07.2020
• Subjects: Animals; Antidepressants; Apoptosis; Bioelectricity; Biomarkers; Brain; Brain research; Brain-derived neurotrophic factor; Circuits; Cytotoxicity; Deactivation; Depression - therapy; Electric fields; FDA approval; Gyrus Cinguli - physiology; Hypothalamic-pituitary-adrenal axis; Hypothalamus; Inactivation; Injection; Iron oxides; Magnetic field; Magnetic fields; Magnetic Iron Oxide Nanoparticles - administration & dosage; Magnetic permeability; Magnetic Phenomena; Magnetic resonance imaging; Male; Mental depression; Mice; Mice, Inbred C57BL; Nanoparticles; Nervous system; Neuroimaging; Neurosciences; Permeability; Physical characteristics; Physical properties; Pituitary; Stimulation; Symptoms; Transcranial magnetic stimulation; United States > US; China; Bioelectronics; Depression; Magnetic stimulation; SPIO nanoparticles

Magnetic brain stimulation has greatly contributed to the advancement of neuroscience. However, challenges remain in the power of penetration and precision of magnetic stimulation, especially in small animals. Here, a novel combined magnetic stimulation system (c-MSS) was established for brain stimu...