Effect of ripasudil after trabeculectomy with mitomycin C: a multicentre, randomised, prospective clinical study

• Published in: BMJ open ophthalmology Vol. 9; no. 1; p. e001449
• Main Authors: Muhlisah, Aisyah, Hirooka, Kazuyuki, Nurtania, Ariyanie, Onoe, Hiromitsu, Okumichi, Hideaki, Nitta, Eri, Baba, Tetsuya, Tanito, Masaki, Matsuoka, Yotaro, Nakakura, Shunsuke, Kiuchi, Yoshiaki
• Format: Journal Article
• Language: English
• Published: England BMJ Publishing Group Ltd 02.07.2024; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Aged; Alkylating Agents - administration & dosage; Alkylating Agents - therapeutic use; Cataracts; Clinical Trial; Collagen; Cross-sectional studies; Eye surgery; Female; Fibroblasts; Glaucoma; Glaucoma, Open-Angle - drug therapy; Glaucoma, Open-Angle - surgery; Hospitals; Humans; Intraocular pressure; Intraocular Pressure - drug effects; Isoquinolines - administration & dosage; Isoquinolines - therapeutic use; Kinases; Male; Middle Aged; Mitomycin - administration & dosage; Mitomycin - therapeutic use; Original Research; Prospective Studies; Proteins; rho-Associated Kinases - antagonists & inhibitors; Scars; Sulfonamides - administration & dosage; Sulfonamides - therapeutic use; Surgical outcomes; Trabeculectomy - methods; Treatment Outcome; Glaucoma; Clinical Trial; Intraocular pressure

BackgroundTo investigate if there are improvements in trabeculectomy outcomes supporting filtration bleb formation caused by Rho-associated protein kinase (ROCK) inhibitors.MethodsThis prospective, multicentre, randomised, open-label clinical study examined open-angle glaucoma patients who underwent...