Randomised placebo-controlled trial of combination ACE inhibitor and beta-blocker therapy to prevent cardiomyopathy in children with Duchenne muscular dystrophy? (DMD Heart Protection Study): a protocol study - Bourke, John P; Watson, Gillian; Muntoni, Francesco; Spinty, Stefan; Roper, Helen; Guglieri, Michela; Speed, Chris; McColl, Elaine; Chikermane, Ashish; Jayawant, Sandeep; Adwani, Satish; Willis, Tracey; et al. (BMJ open, 2018)
Keywords: ace-inhibitor; Adolescent; Adrenergic beta-Antagonists - therapeutic use; Age; Angiotensin-Converting Enzyme Inhibitors - therapeutic use; Beta blockers; beta-blocker; cardiac dystrophinopathy; Cardiology; Cardiomyopathies - etiology; Cardiomyopathies - prevention & control; Cardiomyopathy; Cardiovascular Medicine; Child; Child, Preschool; Children & youth; Clinics; Drug Therapy, Combination; duchenne muscular dystrophy; Echocardiography; Electrocardiography; Evidence-based medicine; Forced Expiratory Volume; Health surveillance; Heart failure; Heart Ventricles - diagnostic imaging; Humans; Male; Medical prognosis; Mortality; Multicenter Studies as Topic; Muscular dystrophy; Muscular Dystrophy, Duchenne - complications; Patients; prophylactic therapy; Randomized Controlled Trials as Topic; Vital Capacity; United Kingdom--UK; prophylactic therapy; duchenne muscular dystrophy; ace-inhibitor; beta-blocker; cardiac dystrophinopathy