Basal Septal Hypertrophy

A significant clinical problem is patients presenting with exercise-limiting dyspnoea, sometimes with associated chest pain, in the absence of detectable left ventricular (LV) systolic dysfunction, coronary artery disease, or lung disease. Often the patients are older, female, and have isolated basa...

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Published inCurrent cardiology reviews Vol. 9; no. 4; pp. 325 - 330
Main Authors Kelshiker, Mihir A, Mayet, Jamil, Unsworth, Beth, Okonko, Darlington O
Format Journal Article
LanguageEnglish
Published United Arab Emirates Bentham Science Publishers Ltd 01.11.2013
Subjects
Cardiomyopathy, Hypertrophic - diagnostic imaging
Diastole - physiology
Dyspnea - etiology
Heart Septum - diagnostic imaging
Heart Septum - pathology
Humans
Hypertrophy - diagnostic imaging
Hypertrophy - etiology
Hypertrophy - physiopathology
Stroke Volume - physiology
Systole - physiology
Ultrasonography
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Abstract A significant clinical problem is patients presenting with exercise-limiting dyspnoea, sometimes with associated chest pain, in the absence of detectable left ventricular (LV) systolic dysfunction, coronary artery disease, or lung disease. Often the patients are older, female, and have isolated basal septal hypertrophy (BSH), frequently on a background of mild hypertension. The topic of breathlessness in patients with clinical heart failure, but who have a normal ejection fraction (HFNEF) has attracted significant controversy over the past few years. This review aims to analyse the literature on BSH, identify the possible associations between BSH and HFNEF, and consequently explore possible pathophysiological mechanisms whereby clinical symptoms are experienced.
AbstractList A significant clinical problem is patients presenting with exercise-limiting dyspnoea, sometimes with associated chest pain, in the absence of detectable left ventricular (LV) systolic dysfunction, coronary artery disease, or lung disease. Often the patients are older, female, and have isolated basal septal hypertrophy (BSH), frequently on a background of mild hypertension. The topic of breathlessness in patients with clinical heart failure, but who have a normal ejection fraction (HFNEF) has attracted significant controversy over the past few years. This review aims to analyse the literature on BSH, identify the possible associations between BSH and HFNEF, and consequently explore possible pathophysiological mechanisms whereby clinical symptoms are experienced.
A significant clinical problem is patients presenting with exercise-limiting dyspnoea, sometimes with associated chest pain, in the absence of detectable left ventricular (LV) systolic dysfunction, coronary artery disease, or lung disease. Often the patients are older, female, and have isolated basal septal hypertrophy (BSH), frequently on a background of mild hypertension. The topic of breathlessness in patients with clinical heart failure, but who have a normal ejection fraction (HFNEF) has attracted significant controversy over the past few years. This review aims to analyse the literature on BSH, identify the possible associations between BSH and HFNEF, and consequently explore possible pathophysiological mechanisms whereby clinical symptoms are experienced.
Author Jamil Mayet
Mihir A. Kelshiker
Darlington O. Okonko
Beth Unsworth
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  surname: Mayet
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  givenname: Darlington O
  surname: Okonko
  fullname: Okonko, Darlington O
  email: mihir.kelshiker10@imperial.ac.uk
  organization: International Center for Circulatory Health, St Mary's Hospital, NHLI, Imperial College London, UK. mihir.kelshiker10@imperial.ac.uk
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SubjectTerms Cardiomyopathy, Hypertrophic - diagnostic imaging
Diastole - physiology
Dyspnea - etiology
Heart Septum - diagnostic imaging
Heart Septum - pathology
Humans
Hypertrophy - diagnostic imaging
Hypertrophy - etiology
Hypertrophy - physiopathology
Stroke Volume - physiology
Systole - physiology
Ultrasonography
Title Basal Septal Hypertrophy
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