Effects of ondansetron applied before the induction of anaesthesia on postoperative nausea and vomiting in high-risk patients: protocol for a randomised controlled trial

• Published in: BMJ open Vol. 15; no. 6; p. e093633
• Main Authors: Bu, Fandong, Zhang, Dongbin, Chi, Yongliang
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 22.06.2025; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Adult; Adult anaesthesia; Anaesthesia; Anesthesia - adverse effects; Antiemetics; Antiemetics - administration & dosage; Antiemetics - therapeutic use; CLINICAL PHARMACOLOGY; Double-Blind Method; Drug dosages; Female; General anesthesia; Hospitals; Humans; Informed consent; Intervention; Male; Medicine; Middle Aged; Narcotics; Nausea; Ondansetron - administration & dosage; Ondansetron - therapeutic use; Patients; Pediatrics; Postoperative Nausea and Vomiting - prevention & control; Protocol; Randomized Controlled Trials as Topic; Risk factors; Surgery; Vomiting; Young Adult; Medicine; Adult anaesthesia; CLINICAL PHARMACOLOGY

IntroductionPostoperative nausea and vomiting (PONV) is a common complication following various surgical procedures, significantly contributing to patient discomfort and increasing healthcare costs. Despite the widespread use of multiple drug combinations, PONV remains a persistent challenge, partic...