Impact of Nutritional Support for Tuberculosis on Intermediate and Terminal Undernutrition and Treatment Outcomes (INSTITUT) study: a protocol for a quasi-experimental study to assess the impact of nutritional support on tuberculosis treatment outcomes in Benin and Togo

• Published in: BMJ open Vol. 15; no. 2; p. e088629
• Main Authors: Cintron, Chelsie, Dauphinais, Madolyn, Fiogbe, Attannon Arnauld, Dogo, Mohammed Fall, Ate, Safiou, Adjonou, Christine, Agossou, Kokou, Pan, Susie Jiaxing, Esse, Marius, Ade, Benjamin, Adjoh, Komi Séraphin, Affolabi, Dissou, Sinha, Pranay, Koura, Kobto G
• Format: Journal Article
• Language: English
• Published: England British Medical Journal Publishing Group 10.02.2025; BMJ Publishing Group LTD; BMJ Publishing Group
• Subjects: Adult; Antitubercular Agents - therapeutic use; At risk populations; Benin - epidemiology; Body mass index; Clinical outcomes; COVID-19; Data collection; Diabetes; Disease; Female; Food; Food Insecurity; Humans; Infectious Diseases; Male; Malnutrition - complications; Malnutrition - diet therapy; Malnutrition - therapy; Medical ethics; Mortality; NUTRITION & DIETETICS; Nutritional status; Nutritional Support - methods; Population; Prospective Studies; Protocol; Public health; Research Design; Togo - epidemiology; Treatment Outcome; Tuberculosis; Tuberculosis, Pulmonary - complications; Tuberculosis, Pulmonary - therapy; Togo; Benin; West Africa; Food Insecurity; NUTRITION & DIETETICS; Tuberculosis; Public health

IntroductionUndernourished persons with tuberculosis (TB) (PWTB) are at increased risk of mortality, treatment failure and relapse. Nutritional support for PWTB has the potential to mitigate the risk of undernutrition. However, given ethical concerns, well-powered randomised control trials of macron...