Tissue inhibitor of metalloproteinase (TIMP)-1 predicts failure of recovery of ejection fraction in acute heart failure with reduced ejection fraction
BackgroundHeart failure (HF) with improved ejection fraction (HFimpEF) is a recently identified phenotype of HF, which had better cardiovascular outcomes compared with persistent HF with reduced ejection fraction (HFrEF). The present study aimed to investigate the predictive value of tissue inhibito...
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| Published in | Open heart Vol. 11; no. 2; p. e002770 |
|---|---|
| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
British Cardiovascular Society
25.09.2024
BMJ Publishing Group LTD BMJ Publishing Group |
| Subjects | |
| Online Access | Get full text |
| ISSN | 2053-3624 2398-595X 2053-3624 |
| DOI | 10.1136/openhrt-2024-002770 |
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| Abstract | BackgroundHeart failure (HF) with improved ejection fraction (HFimpEF) is a recently identified phenotype of HF, which had better cardiovascular outcomes compared with persistent HF with reduced ejection fraction (HFrEF). The present study aimed to investigate the predictive value of tissue inhibitor of metalloproteinase (TIMP)-1 and matrix metalloproteinases-9 (MMP-9) in the recovery of left ventricular ejection fraction (LVEF).MethodsSubjects who presented with acute decompensated HF and reduced LVEF of ≤40% were eligible for this study. HFimpEF was defined by a follow-up LVEF >40% and a ≥10% improvement in LVEF. Overnight fasting N-terminal pro-brain natriuretic peptide (NT-proBNP), MMP-9 and TIMP-1 were measured within 24 hours before discharge. The study participants were followed for up to 5 years.ResultsAmong a total of 91 participants (70.1±16.2 years, baseline LVEF 28.9±7.6%), 19 (20.8%) of them had HFimpEF and 72 (79.2%) had persistent HFrEF at 6 months. The receiver operating characteristic curve analyses showed the area under curve measures for TIMP-1, MMP-9 and NT-proBNP in the prediction of HFimpEF were 0.69, 0.52 and 0.65, respectively. TIMP-1 was negatively correlated with HFimpEF as continuous variables (OR per 1-SD and 95% CI 0.99 (0.98 to 1.00)) and categorical variables (cut-off value 200.68 ng/mL, OR and 95% CI 0.16 (0.05 to 0.54)) after adjustment of confounding factors. During a mean follow-up duration 34.8 months, patients with HFimpEF will have better long-term survival than those with persistent HFrEF.ConclusionsIn subjects with decompensated HFrEF, TIMP-1, but not MMP-9 was associated with the reverse remodelling in LVEF. In addition, patients with HFimpEF would have better long-term survival. |
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| AbstractList | BackgroundHeart failure (HF) with improved ejection fraction (HFimpEF) is a recently identified phenotype of HF, which had better cardiovascular outcomes compared with persistent HF with reduced ejection fraction (HFrEF). The present study aimed to investigate the predictive value of tissue inhibitor of metalloproteinase (TIMP)-1 and matrix metalloproteinases-9 (MMP-9) in the recovery of left ventricular ejection fraction (LVEF).MethodsSubjects who presented with acute decompensated HF and reduced LVEF of ≤40% were eligible for this study. HFimpEF was defined by a follow-up LVEF >40% and a ≥10% improvement in LVEF. Overnight fasting N-terminal pro-brain natriuretic peptide (NT-proBNP), MMP-9 and TIMP-1 were measured within 24 hours before discharge. The study participants were followed for up to 5 years.ResultsAmong a total of 91 participants (70.1±16.2 years, baseline LVEF 28.9±7.6%), 19 (20.8%) of them had HFimpEF and 72 (79.2%) had persistent HFrEF at 6 months. The receiver operating characteristic curve analyses showed the area under curve measures for TIMP-1, MMP-9 and NT-proBNP in the prediction of HFimpEF were 0.69, 0.52 and 0.65, respectively. TIMP-1 was negatively correlated with HFimpEF as continuous variables (OR per 1-SD and 95% CI 0.99 (0.98 to 1.00)) and categorical variables (cut-off value 200.68 ng/mL, OR and 95% CI 0.16 (0.05 to 0.54)) after adjustment of confounding factors. During a mean follow-up duration 34.8 months, patients with HFimpEF will have better long-term survival than those with persistent HFrEF.ConclusionsIn subjects with decompensated HFrEF, TIMP-1, but not MMP-9 was associated with the reverse remodelling in LVEF. In addition, patients with HFimpEF would have better long-term survival. Heart failure (HF) with improved ejection fraction (HFimpEF) is a recently identified phenotype of HF, which had better cardiovascular outcomes compared with persistent HF with reduced ejection fraction (HFrEF). The present study aimed to investigate the predictive value of tissue inhibitor of metalloproteinase (TIMP)-1 and matrix metalloproteinases-9 (MMP-9) in the recovery of left ventricular ejection fraction (LVEF). Subjects who presented with acute decompensated HF and reduced LVEF of ≤40% were eligible for this study. HFimpEF was defined by a follow-up LVEF >40% and a ≥10% improvement in LVEF. Overnight fasting N-terminal pro-brain natriuretic peptide (NT-proBNP), MMP-9 and TIMP-1 were measured within 24 hours before discharge. The study participants were followed for up to 5 years. Among a total of 91 participants (70.1±16.2 years, baseline LVEF 28.9±7.6%), 19 (20.8%) of them had HFimpEF and 72 (79.2%) had persistent HFrEF at 6 months. The receiver operating characteristic curve analyses showed the area under curve measures for TIMP-1, MMP-9 and NT-proBNP in the prediction of HFimpEF were 0.69, 0.52 and 0.65, respectively. TIMP-1 was negatively correlated with HFimpEF as continuous variables (OR per 1-SD and 95% CI 0.99 (0.98 to 1.00)) and categorical variables (cut-off value 200.68 ng/mL, OR and 95% CI 0.16 (0.05 to 0.54)) after adjustment of confounding factors. During a mean follow-up duration 34.8 months, patients with HFimpEF will have better long-term survival than those with persistent HFrEF. In subjects with decompensated HFrEF, TIMP-1, but not MMP-9 was associated with the reverse remodelling in LVEF. In addition, patients with HFimpEF would have better long-term survival. Background Heart failure (HF) with improved ejection fraction (HFimpEF) is a recently identified phenotype of HF, which had better cardiovascular outcomes compared with persistent HF with reduced ejection fraction (HFrEF). The present study aimed to investigate the predictive value of tissue inhibitor of metalloproteinase (TIMP)-1 and matrix metalloproteinases-9 (MMP-9) in the recovery of left ventricular ejection fraction (LVEF).Methods Subjects who presented with acute decompensated HF and reduced LVEF of ≤40% were eligible for this study. HFimpEF was defined by a follow-up LVEF >40% and a ≥10% improvement in LVEF. Overnight fasting N-terminal pro-brain natriuretic peptide (NT-proBNP), MMP-9 and TIMP-1 were measured within 24 hours before discharge. The study participants were followed for up to 5 years.Results Among a total of 91 participants (70.1±16.2 years, baseline LVEF 28.9±7.6%), 19 (20.8%) of them had HFimpEF and 72 (79.2%) had persistent HFrEF at 6 months. The receiver operating characteristic curve analyses showed the area under curve measures for TIMP-1, MMP-9 and NT-proBNP in the prediction of HFimpEF were 0.69, 0.52 and 0.65, respectively. TIMP-1 was negatively correlated with HFimpEF as continuous variables (OR per 1-SD and 95% CI 0.99 (0.98 to 1.00)) and categorical variables (cut-off value 200.68 ng/mL, OR and 95% CI 0.16 (0.05 to 0.54)) after adjustment of confounding factors. During a mean follow-up duration 34.8 months, patients with HFimpEF will have better long-term survival than those with persistent HFrEF.Conclusions In subjects with decompensated HFrEF, TIMP-1, but not MMP-9 was associated with the reverse remodelling in LVEF. In addition, patients with HFimpEF would have better long-term survival. Heart failure (HF) with improved ejection fraction (HFimpEF) is a recently identified phenotype of HF, which had better cardiovascular outcomes compared with persistent HF with reduced ejection fraction (HFrEF). The present study aimed to investigate the predictive value of tissue inhibitor of metalloproteinase (TIMP)-1 and matrix metalloproteinases-9 (MMP-9) in the recovery of left ventricular ejection fraction (LVEF).BACKGROUNDHeart failure (HF) with improved ejection fraction (HFimpEF) is a recently identified phenotype of HF, which had better cardiovascular outcomes compared with persistent HF with reduced ejection fraction (HFrEF). The present study aimed to investigate the predictive value of tissue inhibitor of metalloproteinase (TIMP)-1 and matrix metalloproteinases-9 (MMP-9) in the recovery of left ventricular ejection fraction (LVEF).Subjects who presented with acute decompensated HF and reduced LVEF of ≤40% were eligible for this study. HFimpEF was defined by a follow-up LVEF >40% and a ≥10% improvement in LVEF. Overnight fasting N-terminal pro-brain natriuretic peptide (NT-proBNP), MMP-9 and TIMP-1 were measured within 24 hours before discharge. The study participants were followed for up to 5 years.METHODSSubjects who presented with acute decompensated HF and reduced LVEF of ≤40% were eligible for this study. HFimpEF was defined by a follow-up LVEF >40% and a ≥10% improvement in LVEF. Overnight fasting N-terminal pro-brain natriuretic peptide (NT-proBNP), MMP-9 and TIMP-1 were measured within 24 hours before discharge. The study participants were followed for up to 5 years.Among a total of 91 participants (70.1±16.2 years, baseline LVEF 28.9±7.6%), 19 (20.8%) of them had HFimpEF and 72 (79.2%) had persistent HFrEF at 6 months. The receiver operating characteristic curve analyses showed the area under curve measures for TIMP-1, MMP-9 and NT-proBNP in the prediction of HFimpEF were 0.69, 0.52 and 0.65, respectively. TIMP-1 was negatively correlated with HFimpEF as continuous variables (OR per 1-SD and 95% CI 0.99 (0.98 to 1.00)) and categorical variables (cut-off value 200.68 ng/mL, OR and 95% CI 0.16 (0.05 to 0.54)) after adjustment of confounding factors. During a mean follow-up duration 34.8 months, patients with HFimpEF will have better long-term survival than those with persistent HFrEF.RESULTSAmong a total of 91 participants (70.1±16.2 years, baseline LVEF 28.9±7.6%), 19 (20.8%) of them had HFimpEF and 72 (79.2%) had persistent HFrEF at 6 months. The receiver operating characteristic curve analyses showed the area under curve measures for TIMP-1, MMP-9 and NT-proBNP in the prediction of HFimpEF were 0.69, 0.52 and 0.65, respectively. TIMP-1 was negatively correlated with HFimpEF as continuous variables (OR per 1-SD and 95% CI 0.99 (0.98 to 1.00)) and categorical variables (cut-off value 200.68 ng/mL, OR and 95% CI 0.16 (0.05 to 0.54)) after adjustment of confounding factors. During a mean follow-up duration 34.8 months, patients with HFimpEF will have better long-term survival than those with persistent HFrEF.In subjects with decompensated HFrEF, TIMP-1, but not MMP-9 was associated with the reverse remodelling in LVEF. In addition, patients with HFimpEF would have better long-term survival.CONCLUSIONSIn subjects with decompensated HFrEF, TIMP-1, but not MMP-9 was associated with the reverse remodelling in LVEF. In addition, patients with HFimpEF would have better long-term survival. |
| Author | Tseng, Chih-Hsueh Cheng, Hao-Min Sung, Shih-Hsien Chang, Hao-Chih Chen, Chen-Huan Yu, Wen-Chung Chiang, Chern-En Huang, Wei-Ming |
| Author_xml | – sequence: 1 givenname: Chih-Hsueh surname: Tseng fullname: Tseng, Chih-Hsueh organization: Institute of Emergency and Critical Care Medicine, National Yang-Ming Chiao-Tung University, Taipei, Taiwan – sequence: 2 givenname: Wei-Ming surname: Huang fullname: Huang, Wei-Ming organization: Department of Medicine, Kinmen Hospital, Ministry of Health and Welfare, Jinhu, Taiwan – sequence: 3 givenname: Hao-Chih surname: Chang fullname: Chang, Hao-Chih organization: Department of Medicine, Taipei Veterans General Hospital Taoyuan Branch, Taoyuan, Taiwan – sequence: 4 givenname: Wen-Chung orcidid: 0000-0003-3899-0022 surname: Yu fullname: Yu, Wen-Chung organization: Department of Internal Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan – sequence: 5 givenname: Hao-Min surname: Cheng fullname: Cheng, Hao-Min organization: Department of Medical Education, Taipei Veterans General Hospital, Taipei, Taiwan – sequence: 6 givenname: Chern-En surname: Chiang fullname: Chiang, Chern-En organization: Cardiovascular Research Center, National Yang-Ming Chiao Tung University, Taipei, Taiwan – sequence: 7 givenname: Chen-Huan surname: Chen fullname: Chen, Chen-Huan organization: Cardiovascular Research Center, National Yang-Ming Chiao Tung University, Taipei, Taiwan – sequence: 8 givenname: Shih-Hsien orcidid: 0000-0002-6256-2194 surname: Sung fullname: Sung, Shih-Hsien email: mr.sungsh@gmail.com organization: Cardiovascular Research Center, National Yang-Ming Chiao Tung University, Taipei, Taiwan |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/39322629$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.3389/fcvm.2021.757596 10.1016/j.jacc.2018.11.042 10.1161/HYPERTENSIONAHA.117.09045 10.1093/eurjhf/hfq037 10.3389/fcvm.2021.586240 10.1016/j.jacc.2010.11.030 10.1093/eurjhf/hfs124 10.1161/CIR.0000000000001063 10.1016/j.echo.2014.10.003 10.1016/j.cardfail.2006.05.012 10.1111/j.1540-8159.2007.00870.x 10.1161/01.res.0000013290.12884.a3 10.1056/NEJMoa1911303 10.1016/j.jchf.2019.06.004 10.1161/CIRCHEARTFAILURE.116.003123 10.1161/hc3401.093154 10.1016/s1053-2498(02)00557-0 10.1161/01.res.82.4.482 10.1016/j.jchf.2018.10.014 10.1253/circj.CJ-15-0964 10.1002/cphy.c140045 10.1016/j.ejheart.2008.02.015 10.1016/j.jacc.2012.07.072 10.1016/j.jacc.2010.05.011 10.1016/j.ijcard.2015.02.019 10.1007/s10059-011-0023-9 10.1161/JAHA.118.011077 10.1056/NEJMoa1409077 10.1161/01.cir.103.18.2303 10.1002/ehf2.12137 10.1161/cir.0000000000001063 10.1161/01.CIR.103.18.2303 10.1161/01.RES.0000013290.12884.A3 10.1002/j.2040-4603.2015.tb00624.x 10.1161/01.RES.82.4.482 10.1016/S1053-2498(02)00557-0 |
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| Keywords | Biomarkers Echocardiography Heart Failure, Systolic Cardiomyopathy, Dilated |
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| References | Lilli, Ricciardi, Porciani (R17) 2007; 30 Barton, Birks, Felkin (R18) 2003; 22 Ye, Li, Wang (R5) 2021; 8 Park, Park, Mebazaa (R15) 2019; 8 Lu, Liu, Zhang (R26) 2011; 31 Yan, Yan, Spinale (R21) 2006; 12 McMurray, Solomon, Inzucchi (R30) 2019; 381 Florea, Rector, Anand (R2) 2016; 9 Frantz, Störk, Michels (R9) 2008; 10 Zile, O’Meara, Claggett (R10) 2019; 73 Spinale, Coker, Thomas (R20) 1998; 82 Sivasubramanian, Coker, Kurrelmeyer (R19) 2001; 104 Daubert, Adams, Yow (R27) 2019; 7 He, Ling, Guo (R14) 2021; 8 Morishita, Uzui, Mitsuke (R23) 2017; 4 Tolosana, Mont, Sitges (R25) 2010; 12 Merlo, Pyxaras, Pinamonti (R3) 2011; 57 Takawale, Zhang, Patel (R24) 2017; 69 Kramer, Trikalinos, Kent (R16) 2010; 56 Aimo, Gaggin, Barison (R4) 2019; 7 Lupón, Gaggin, de Antonio (R6) 2015; 184 Lang, Badano, Mor-Avi (R13) 2015; 28 Takawale, Sakamuri, Kassiri (R8) 2015; 5 Huang, Hsu, Cheng (R12) 2016; 80 Heidenreich, Bozkurt, Aguilar (R1) 2022; 145 Peterson, Hallak, Johnson (R22) 2001; 103 McMurray, Packer, Desai (R29) 2014; 371 Sung, Yu, Cheng (R11) 2012; 14 Spinale (R7) 2002; 90 Kubanek, Sramko, Maluskova (R28) 2013; 61 Takawale (2025081711113599000_11.2.e002770.8) 2015; 5 Florea (2025081711113599000_11.2.e002770.2) 2016; 9 2025081711113599000_11.2.e002770.4 2025081711113599000_11.2.e002770.3 Ye (2025081711113599000_11.2.e002770.5) 2021; 8 2025081711113599000_11.2.e002770.1 He (2025081711113599000_11.2.e002770.14) 2021; 8 Park (2025081711113599000_11.2.e002770.15) 2019; 8 2025081711113599000_11.2.e002770.20 2025081711113599000_11.2.e002770.21 Lupón (2025081711113599000_11.2.e002770.6) 2015; 184 2025081711113599000_11.2.e002770.22 2025081711113599000_11.2.e002770.24 2025081711113599000_11.2.e002770.25 2025081711113599000_11.2.e002770.26 2025081711113599000_11.2.e002770.27 2025081711113599000_11.2.e002770.28 2025081711113599000_11.2.e002770.29 Huang (2025081711113599000_11.2.e002770.12) 2016; 80 2025081711113599000_11.2.e002770.30 2025081711113599000_11.2.e002770.9 2025081711113599000_11.2.e002770.10 2025081711113599000_11.2.e002770.7 2025081711113599000_11.2.e002770.11 2025081711113599000_11.2.e002770.13 2025081711113599000_11.2.e002770.16 2025081711113599000_11.2.e002770.17 Morishita (2025081711113599000_11.2.e002770.23) 2017; 4 2025081711113599000_11.2.e002770.18 2025081711113599000_11.2.e002770.19 |
| References_xml | – volume: 8 year: 2021 ident: R14 article-title: Prevalence and Prognosis of HFimpEF Developed From Patients With Heart Failure With Reduced Ejection Fraction: Systematic Review and Meta-Analysis publication-title: Front Cardiovasc Med doi: 10.3389/fcvm.2021.757596 – volume: 73 start-page: 795 year: 2019 ident: R10 article-title: Effects of Sacubitril/Valsartan on Biomarkers of Extracellular Matrix Regulation in Patients With HFrEF publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2018.11.042 – volume: 69 start-page: 1092 year: 2017 ident: R24 article-title: Tissue Inhibitor of Matrix Metalloproteinase-1 Promotes Myocardial Fibrosis by Mediating CD63-Integrin β1 Interaction publication-title: Hypertension doi: 10.1161/HYPERTENSIONAHA.117.09045 – volume: 12 start-page: 492 year: 2010 ident: R25 article-title: Plasma tissue inhibitor of matrix metalloproteinase-1 (TIMP-1): an independent predictor of poor response to cardiac resynchronization therapy publication-title: Eur J Heart Fail doi: 10.1093/eurjhf/hfq037 – volume: 8 year: 2021 ident: R5 article-title: Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure publication-title: Front Cardiovasc Med doi: 10.3389/fcvm.2021.586240 – volume: 57 start-page: 1468 year: 2011 ident: R3 article-title: Prevalence and prognostic significance of left ventricular reverse remodeling in dilated cardiomyopathy receiving tailored medical treatment publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2010.11.030 – volume: 14 start-page: 1348 year: 2012 ident: R11 article-title: Excessive wave reflections on admission predict post-discharge events in patients hospitalized due to acute heart failure publication-title: Eur J Heart Fail doi: 10.1093/eurjhf/hfs124 – volume: 145 start-page: e895 year: 2022 ident: R1 article-title: 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines publication-title: Circulation doi: 10.1161/CIR.0000000000001063 – volume: 28 start-page: 1 year: 2015 ident: R13 article-title: Recommendations for cardiac chamber quantification by echocardiography in adults: an update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging publication-title: J Am Soc Echocardiogr doi: 10.1016/j.echo.2014.10.003 – volume: 12 start-page: 514 year: 2006 ident: R21 article-title: Plasma matrix metalloproteinase-9 level is correlated with left ventricular volumes and ejection fraction in patients with heart failure publication-title: J Card Fail doi: 10.1016/j.cardfail.2006.05.012 – volume: 30 start-page: 1349 year: 2007 ident: R17 article-title: Cardiac resynchronization therapy: gender related differences in left ventricular reverse remodeling publication-title: Pacing Clin Electrophysiol doi: 10.1111/j.1540-8159.2007.00870.x – volume: 90 start-page: 520 year: 2002 ident: R7 article-title: Matrix metalloproteinases: regulation and dysregulation in the failing heart publication-title: Circ Res doi: 10.1161/01.res.0000013290.12884.a3 – volume: 381 start-page: 1995 year: 2019 ident: R30 article-title: Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction publication-title: N Engl J Med doi: 10.1056/NEJMoa1911303 – volume: 7 start-page: 782 year: 2019 ident: R4 article-title: Imaging, Biomarker, and Clinical Predictors of Cardiac Remodeling in Heart Failure With Reduced Ejection Fraction publication-title: JACC Heart Fail doi: 10.1016/j.jchf.2019.06.004 – volume: 9 year: 2016 ident: R2 article-title: Heart Failure With Improved Ejection Fraction: Clinical Characteristics, Correlates of Recovery, and Survival: Results From the Valsartan Heart Failure Trial publication-title: Circ Heart Fail doi: 10.1161/CIRCHEARTFAILURE.116.003123 – volume: 104 start-page: 826 year: 2001 ident: R19 article-title: Left ventricular remodeling in transgenic mice with cardiac restricted overexpression of tumor necrosis factor publication-title: Circulation doi: 10.1161/hc3401.093154 – volume: 22 start-page: 738 year: 2003 ident: R18 article-title: Increased expression of extracellular matrix regulators TIMP1 and MMP1 in deteriorating heart failure publication-title: J Heart Lung Transplant doi: 10.1016/s1053-2498(02)00557-0 – volume: 82 start-page: 482 year: 1998 ident: R20 article-title: Time-dependent changes in matrix metalloproteinase activity and expression during the progression of congestive heart failure: relation to ventricular and myocyte function publication-title: Circ Res doi: 10.1161/01.res.82.4.482 – volume: 7 start-page: 158 year: 2019 ident: R27 article-title: NT-proBNP Goal Achievement Is Associated With Significant Reverse Remodeling and Improved Clinical Outcomes in HFrEF publication-title: JACC Heart Fail doi: 10.1016/j.jchf.2018.10.014 – volume: 80 start-page: 404 year: 2016 ident: R12 article-title: Determinants and Prognostic Impact of Hyperuricemia in Hospitalization for Acute Heart Failure publication-title: Circ J doi: 10.1253/circj.CJ-15-0964 – volume: 5 start-page: 687 year: 2015 ident: R8 article-title: Extracellular matrix communication and turnover in cardiac physiology and pathology publication-title: Compr Physiol doi: 10.1002/cphy.c140045 – volume: 10 start-page: 388 year: 2008 ident: R9 article-title: Tissue inhibitor of metalloproteinases levels in patients with chronic heart failure: an independent predictor of mortality publication-title: Eur J Heart Fail doi: 10.1016/j.ejheart.2008.02.015 – volume: 61 start-page: 54 year: 2013 ident: R28 article-title: Novel predictors of left ventricular reverse remodeling in individuals with recent-onset dilated cardiomyopathy publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2012.07.072 – volume: 56 start-page: 392 year: 2010 ident: R16 article-title: Quantitative evaluation of drug or device effects on ventricular remodeling as predictors of therapeutic effects on mortality in patients with heart failure and reduced ejection fraction: a meta-analytic approach publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2010.05.011 – volume: 184 start-page: 337 year: 2015 ident: R6 article-title: Biomarker-assist score for reverse remodeling prediction in heart failure: The ST2-R2 score publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2015.02.019 – volume: 31 start-page: 225 year: 2011 ident: R26 article-title: Tissue inhibitor of metalloproteinase-1 promotes NIH3T3 fibroblast proliferation by activating p-Akt and cell cycle progression publication-title: Mol Cells doi: 10.1007/s10059-011-0023-9 – volume: 8 year: 2019 ident: R15 article-title: Characteristics, Outcomes, and Treatment of Heart Failure With Improved Ejection Fraction publication-title: J Am Heart Assoc doi: 10.1161/JAHA.118.011077 – volume: 371 start-page: 993 year: 2014 ident: R29 article-title: Angiotensin-neprilysin inhibition versus enalapril in heart failure publication-title: N Engl J Med doi: 10.1056/NEJMoa1409077 – volume: 103 start-page: 2303 year: 2001 ident: R22 article-title: Matrix metalloproteinase inhibition attenuates left ventricular remodeling and dysfunction in a rat model of progressive heart failure publication-title: Circulation doi: 10.1161/01.cir.103.18.2303 – volume: 4 start-page: 321 year: 2017 ident: R23 article-title: Association between matrix metalloproteinase-9 and worsening heart failure events in patients with chronic heart failure publication-title: ESC Heart Fail doi: 10.1002/ehf2.12137 – ident: 2025081711113599000_11.2.e002770.11 doi: 10.1093/eurjhf/hfs124 – volume: 8 year: 2019 ident: 2025081711113599000_11.2.e002770.15 article-title: Characteristics, Outcomes, and Treatment of Heart Failure With Improved Ejection Fraction publication-title: J Am Heart Assoc doi: 10.1161/JAHA.118.011077 – ident: 2025081711113599000_11.2.e002770.28 doi: 10.1016/j.jacc.2012.07.072 – volume: 80 start-page: 404 year: 2016 ident: 2025081711113599000_11.2.e002770.12 article-title: Determinants and Prognostic Impact of Hyperuricemia in Hospitalization for Acute Heart Failure publication-title: Circ J doi: 10.1253/circj.CJ-15-0964 – ident: 2025081711113599000_11.2.e002770.10 doi: 10.1016/j.jacc.2018.11.042 – ident: 2025081711113599000_11.2.e002770.17 doi: 10.1111/j.1540-8159.2007.00870.x – ident: 2025081711113599000_11.2.e002770.4 doi: 10.1016/j.jchf.2019.06.004 – ident: 2025081711113599000_11.2.e002770.25 doi: 10.1093/eurjhf/hfq037 – volume: 184 start-page: 337 year: 2015 ident: 2025081711113599000_11.2.e002770.6 article-title: Biomarker-assist score for reverse remodeling prediction in heart failure: The ST2-R2 score publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2015.02.019 – ident: 2025081711113599000_11.2.e002770.1 doi: 10.1161/cir.0000000000001063 – volume: 8 year: 2021 ident: 2025081711113599000_11.2.e002770.14 article-title: Prevalence and Prognosis of HFimpEF Developed From Patients With Heart Failure With Reduced Ejection Fraction: Systematic Review and Meta-Analysis publication-title: Front Cardiovasc Med doi: 10.3389/fcvm.2021.757596 – ident: 2025081711113599000_11.2.e002770.21 doi: 10.1016/j.cardfail.2006.05.012 – volume: 8 year: 2021 ident: 2025081711113599000_11.2.e002770.5 article-title: Body Mass Index: An Effective Predictor of Ejection Fraction Improvement in Heart Failure publication-title: Front Cardiovasc Med doi: 10.3389/fcvm.2021.586240 – ident: 2025081711113599000_11.2.e002770.24 doi: 10.1161/HYPERTENSIONAHA.117.09045 – ident: 2025081711113599000_11.2.e002770.22 doi: 10.1161/01.CIR.103.18.2303 – ident: 2025081711113599000_11.2.e002770.19 doi: 10.1161/hc3401.093154 – ident: 2025081711113599000_11.2.e002770.26 doi: 10.1007/s10059-011-0023-9 – ident: 2025081711113599000_11.2.e002770.7 doi: 10.1161/01.RES.0000013290.12884.A3 – ident: 2025081711113599000_11.2.e002770.27 doi: 10.1016/j.jchf.2018.10.014 – ident: 2025081711113599000_11.2.e002770.30 doi: 10.1056/NEJMoa1911303 – volume: 5 start-page: 687 year: 2015 ident: 2025081711113599000_11.2.e002770.8 article-title: Extracellular matrix communication and turnover in cardiac physiology and pathology publication-title: Compr Physiol doi: 10.1002/j.2040-4603.2015.tb00624.x – volume: 9 year: 2016 ident: 2025081711113599000_11.2.e002770.2 article-title: Heart Failure With Improved Ejection Fraction: Clinical Characteristics, Correlates of Recovery, and Survival: Results From the Valsartan Heart Failure Trial publication-title: Circ Heart Fail doi: 10.1161/CIRCHEARTFAILURE.116.003123 – volume: 4 start-page: 321 year: 2017 ident: 2025081711113599000_11.2.e002770.23 article-title: Association between matrix metalloproteinase-9 and worsening heart failure events in patients with chronic heart failure publication-title: ESC Heart Fail doi: 10.1002/ehf2.12137 – ident: 2025081711113599000_11.2.e002770.29 doi: 10.1056/NEJMoa1409077 – ident: 2025081711113599000_11.2.e002770.13 doi: 10.1016/j.echo.2014.10.003 – ident: 2025081711113599000_11.2.e002770.20 doi: 10.1161/01.RES.82.4.482 – ident: 2025081711113599000_11.2.e002770.3 doi: 10.1016/j.jacc.2010.11.030 – ident: 2025081711113599000_11.2.e002770.9 doi: 10.1016/j.ejheart.2008.02.015 – ident: 2025081711113599000_11.2.e002770.18 doi: 10.1016/S1053-2498(02)00557-0 – ident: 2025081711113599000_11.2.e002770.16 doi: 10.1016/j.jacc.2010.05.011 |
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| Snippet | BackgroundHeart failure (HF) with improved ejection fraction (HFimpEF) is a recently identified phenotype of HF, which had better cardiovascular outcomes... Heart failure (HF) with improved ejection fraction (HFimpEF) is a recently identified phenotype of HF, which had better cardiovascular outcomes compared with... Background Heart failure (HF) with improved ejection fraction (HFimpEF) is a recently identified phenotype of HF, which had better cardiovascular outcomes... |
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| SubjectTerms | Acute coronary syndromes Acute Disease Aged Aged, 80 and over Biomarkers Biomarkers - blood Cardiomyopathy, Dilated Cardiovascular disease Chronic obstructive pulmonary disease Echocardiography Ejection fraction Female Flow velocity Follow-Up Studies Gender Heart attacks Heart failure Heart Failure - blood Heart Failure - diagnosis Heart Failure - physiopathology Heart Failure and Cardiomyopathies Heart Failure, Systolic Hospitalization Humans Male Matrix Metalloproteinase 9 - blood Medical prognosis Middle Aged Mortality Natriuretic Peptide, Brain - blood Original Research Peptide Fragments - blood Peptides Predictive Value of Tests Prognosis Prospective Studies Pulmonary arteries R&D Recovery of Function Research & development Stroke Volume - physiology Time Factors Tissue Inhibitor of Metalloproteinase-1 - blood Ventricular Function, Left - physiology |
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| Title | Tissue inhibitor of metalloproteinase (TIMP)-1 predicts failure of recovery of ejection fraction in acute heart failure with reduced ejection fraction |
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